I-Mitochondria yenza okungaphezu nje kokunikeza amandla kumaseli.
Isikhathi sokufunda esilinganiselwe: 9 imizuzu
Ungangizwa kabi. Banakho konke ukukwenza ngamandla. Futhi ngenxa yokuthi zibaluleke kakhulu ekukhiqizeni amandla, zidlala indima ebalulekile kumetabolism. Futhi ngenxa yalokho, bayisiteji esimaphakathi emkhakheni we-Metabolic Psychiatry.
Sizwa ukuthi i-mitochondria iyimithombo yamandla yeseli yonke indawo. Noma okungenani ngenza emibuthanweni engihlanganyela kuyo. Futhi uzokubona kushiwo kuwo wonke amaposi ebhulogi kule webhusayithi. Ukuxhumana ukuthi i-mitochondria iyizinqaba zamaseli akho kuyindlela elula nelula kakhulu yokufinyelela kuwe oyidingayo ukuze uthole amandla e-neuronal. Kulula ukukuqonda. Uma singenawo amabhethri asebenzayo ku-flashlight, ithoshi ngeke lisebenze. Futhi uma amabhethri ethu efa, azosebenza, kodwa hhayi kahle kakhulu. Futhi lokho kuya ebuchosheni bethu lapho sinokungasebenzi kahle kwe-mitochondrial okuqhubekayo. Amaseli awakwazi ukwenza umsebenzi omningi okudingeka awenze ukuze akugcine uvungama kahle.
Kepha kulabo kini abafuna ukwazi okwengeziwe, kubalulekile ukwazi ukuthi i-mitochondria INGABE KAKHULU kunezindlu zamandla zamaseli akho. Ngakho-ke ngentshisekelo yokuqonda okuthe xaxa okuphelele kokuthi lezi organelles ezincane ezinomlingo ngizibhalele ini le bhulogi!
Qaphela: Angilisebenzisi kalula igama elithi umlingo. Uma ungalithandi igama elithi umlingo, nakanjani, shintsha igama elithi quantum. Ngoba lokho kunembile futhi kuhle kakhulu kupholile. Kodwa ngale kobubanzi balesi sihloko esincane (angiyena uchwepheshe wefiziksi).
I-Mitochondria ihumusha phakathi kwe-quantum ne-macroscopic imihlaba kanye sebenzisa i-quantum tunneling yama-electron ukunciphisa imigoqo yokuvula amandla ekugelezeni kwama-electron. I-electron tunneling ibonakala kakhulu ku-Complex I yochungechunge lwezokuthutha lwe-electron.
U-Bennett, JP (2019). I-hypothesis yezokwelapha: Izifo ze-neurodeergenerative zivela emonakalweni we-oxidative kumaprotheni e-electron tunneling ku-mitochondria. Imibono yezokwelapha, 127, I-1-4.
Ngakho-ke ake singene kwezinye izinto i-mitochondria edlala indima ebalulekile ngaphandle nje kokukhiqizwa kwamandla okumangalisayo. Uma ubunethemba le-athikili ye-mitochondria eqondene nokudla kwe-ketogenic, usenhlanhleni. Ngoba ngibhale eyodwa. Ungayithola lapha:
Ukusabela ngokucindezeleka
Kukhona izingcindezi zomzimba kanye nezingcindezi zengqondo. Futhi ikhono lomzimba wakho lokusingatha izingcindezi zanoma yiluphi uhlobo lehlela ekusebenzeni kwe-mitochondrial. Ingabe uke wachayeka egciwaneni noma ebhaktheriya elicindezela amasosha akho omzimba? I-Mitochondria ilawula ukusebenza kwamasosha omzimba wakho. Ingabe ubhekene nokucindezeleka kwengqondo okukubekela inselele empilweni yakho? I-Mitochondria iphethe ikhono leseli lakho lokuzivumelanisa nezimo, liphile futhi libe namandla ngokwengeziwe ngokuqala izinguquko kukho kokubili ukubonakaliswa kwezakhi zofuzo kanye ne-metabolism. Uma ungenayo i-mitochondria enempilo futhi eningi yokusekela amaseli kusho ukuthi amaseli amaningi ayafa, noma okubi nakakhulu. Aphenduka abe ama-Zombies (senescence) akhipha amasiginali okuvuvukala akhuphula ingcindezi ye-oxidative futhi enze izimpawu zakho zibe zimbi.
Ukukhiqizwa kwamahomoni
Uma kuyingqamuzana eyenza amahomoni, iyingqamuzana edinga amandla amaningi kunamaningi futhi lokho kusho ukuthi i-mitochondria yakho iphethe ngokuyisisekelo ukuhlanganiswa kwehomoni. Kulungile. Amahomoni e-Sterol afana ne-estrogen, i-testosterone, ne-cortisol. I-Mitochondria ibambe ukhiye. Ngaphansi kokuhlinzeka ngama-enzyme adingekayo ukuze kuqalwe ukukhiqizwa kwamahomoni.
Kungakho ukwelashwa kwakho komuthi osebenzayo wokukhathala kwe-adrenal kungasebenzi. Ukukunikeza ama-sterol ezitshalo esikhundleni se-cortisol yakho akubheki ukungasebenzi kahle kwe-mitochondrial okuqhubekayo. Yingakho ukuya ekwelashweni kokubuyisela ama-hormone empeleni akuyona "imbangela eyinhloko" yokungenelela. Uma amahomoni akho engasebenzi kahle, kuwuphawu lokungasebenzi kahle kwe-mitochondrial. Iphuzu lokungenelela ukuthuthukisa umsebenzi wakho we-mitochondrial.
Tshela abangani bakho.
Ukuhlanza amagciwane
Cishe yonke indatshana ekule webhusayithi ikhuluma ngendima yengcindezi ye-oxidative ekuguleni kwengqondo kanye nokuphazamiseka kwemizwa. Ukucindezeleka kwe-oxidative yilokho esikubiza ngokuthi umthwalo wokuzama ukulungisa umonakalo owenzeka ngenxa ye-Reactive Oxygen Species (ROS). Uma i-mitochondria yakho iyinala futhi inempilo ngokuvamile unalo lonke usizo oludingayo ukuze ulungise amazinga avamile omonakalo owenzeka kusukela uphila futhi uhamba emhlabeni.
…mitochondria isebenza njengabagcini bezindlu be-ROS.
(Palmer, 2022, ikhasi 126)
Kudingeka i-mitochondria eningi futhi esebenza kahle ukuze kugcinwe ingcindezi ye-oxidative. Futhi ukugcina ukucindezeleka okwenziwe nge-oxidative kuyadingeka ukuze ube nobuchopho obusebenzayo. Ukucindezelwa kwe-oxidative okungalawulwa kuholela ezinkambisweni ze-neurodegenerative ezithinta imizwa nokusebenza kwengqondo. I-Mitochondria ziwusizo kakhulu ekusebenzeni nasekugcinweni kwezinhlelo ze-antioxidant zangaphakathi zomzimba wakho. Futhi njengoba ngishilo kaningi kuzo zonke izihloko zebhulogi, ngeke usebenzise i-Vitamin C, i-turmeric, noma i-curcumin indlela yakho yokuphuma emthwalweni we-oxidative wokucindezeleka ovela ekusebenzeni kabi noma izinombolo ezinganele ze-mitochondria.
Buza noma iyiphi inombolo yabantu abathatha imithamo emikhulu yama-antioxidant ngokwesincomo sabo sodokotela abasebenza ngemithi abasazabalaza ukuzizwa bephilile.
Tshela abangani bakho ngaleyo ngxenye, nabo.
Uma usadidekile kancane ngomehluko phakathi kwengcindezi ye-oxidative kanye ne-neuroinflammation nokuthi zihlobene kanjani, ungabheka lesi sihloko ngezansi:
Kepha i-mitochondria ingaphezulu kakhulu kweqembu lokuhlanza lapho kuvela isiphithiphithi. Basiza ukugcina amaseli ngazo zonke izinhlobo zezindlela. Alawula inani lamaseli adaliwe, asiza ukulawula ukuthi yikuphi ukuxhumana okunqanyulwayo nokuthi yikuphi okuhlalayo, futhi awusizo enqubweni yokugaywa kabusha eyingxenye yokusebenza kwamaseli okunempilo (i-autophagy, i-apoptosis yeseli - uhlobo oluhle lokufa kweseli). Akukhona nje ukuhlanza ukungcola ngemva kokwenzeka. I-Mitochondria iqinisekisa ukubonakaliswa kwezakhi zofuzo okunempilo nokusebenza kweseli ukuze kuncishiswe amathuba okuthi kuzokwenzeka umonakalo omkhulu kwasekuqaleni.
Isisho se-Gene
Okubalulekile lapha ukuthi izakhi zakho zofuzo ngeke ziziveze kahle ngaphandle kwe-mitochondria esebenzayo enempilo. Cishe eminyakeni engu-20 edlule bathole ukuthi i-mitochondria yayidingeka ukuze kuthuthwe iphrotheni eyasiza ukulawula ukubonakaliswa kofuzo. I-Mitochondria ine-DNA yayo nokuthi amakhodi e-DNA amaprotheni alawula ukubonakaliswa kofuzo. Futhi leyo nkulumo yofuzo inemiphumela ekuphenduleni kokucindezeleka, i-metabolism, kanye nomsebenzi we-antioxidant. Lapho abacwaningi bedlala ne-mitochondria ngokuyiphula (ukunciphisa amandla abo okusebenza) bathola ukuthi izinkinga eziningi ze-epigenetic zenzeka.
Kusho ukuthini lokho?
Kusho ukuthi uma ungafuni ukuthi izakhi zakho zofuzo ziziveze ngezindlela ezijabulisayo ezidala izinkinga nezimpawu futhi zenze wena (kanye nobuchopho bakho) uguge ngokushesha, kungcono ubeke ukugxila kwakho ekufundeni indlela yokuba ne-kick-ass enempilo, kanye ne-mitochondria ejabulisayo.
Uma ubunethemba lokuqonda kangcono ukuthi ama-ketones athonya kanjani ukubonakaliswa kofuzo, ungase uthande lesi sihloko engisibhale lapha:
I-Neurotransmitter Synthesis
I-Mitochondria ithanda ukuhlala kuma-synapses. Uma i-mitochondria yakho iyingcosana ngenombolo noma okuthile kuphazamisa ikhono labo lokuhamba lapho bedingeka khona, awuwenzi ama-neurotransmitters akho. Futhi uma i-mitochondria yakho iyingcosana ngenani noma ingasebenzi kahle noma igula khona-ke ama-neurotransmitters angase angalingani.
Futhi ama-neurotransmitters angalingani aholeli kuphela ezinkingeni zemizwa kodwa nezinkinga zokuqonda, futhi. Udinga i-mitochondria enempilo futhi eningi ukuze uhlanganise, ukhulule, futhi uphinde uthathe ama-neurotransmitters akho bese ukhiqiza ama-enzyme awaphula. Ngiyazi ukuthi sonke sicabanga ukuthi umbono uwukuba nama-neurotransmitters akho ahlale isikhathi eside kuma-synapses, kodwa lokho kungabangela isethi yawo yezinkinga lapho zingakwazi ukuphulwa.
I-loop yempendulo. Ama-neurotransmitters akhiqizwa futhi asetshenziswa abe esenikeza imiyalezo ebalulekile ye-mitochondria esetshenziselwa ukwenza ngcono ukusebenza kobuchopho bakho. Akekho umuntu olwela impumelelo yakho ekusebenzeni kobuchopho njengabangane bakho abanamandla, abancane be-mitochondrial. Ubani ojabulela ukuzuza kwemizwa yakho ezinzile? Ubani ofuna uzizwe uhlakaniphile, ukhona, futhi unekhono?
I-mitochondria yakho.
Kodokotela bengqondo abasebenzisa ngokuyinhloko imithi yokuzama ukwandisa noma ukunciphisa ama-neurotransmitters athile ngaphandle kokucabangela impilo ye-mitochondrial, ngikukhuthaza ukuthi uhlole amanye amathuba okuqeqeshwa kwe-Metabolic Psychiatry anikezwe ekhasini elingezansi.
Isiphetho
Uma ungazange ugxile kwenye indawo yomsebenzi othuthukisiwe ekululameni kwakho kunokusebenza kwe-mitochondrial, uzobe uzenzela isevisi enhle kakhulu. Kunezindlela ezinhle kakhulu zokuthuthukisa umsebenzi we-mitochondrial, futhi enye yezindlela zokungenelela ezinamandla kakhulu zokwandisa inombolo ye-mitochondrial kanye nokusebenza okuthuthukisiwe kwe-mitochondrial kuhlanganisa ukudla kwe-ketogenic.
Kungani? Ngoba ukudla kwe-ketogenic kwandisa inani le-mitochondria futhi kuthuthukise impilo nokusebenza kwe-mitochondria. Ukudla kwe-ketogenic ukungenelela kwe-mitochondrial okuthinta umzimba kanye nayo yonke eminye imisebenzi ebalulekile ebaluleke kakhulu ekusebenzeni kobuchopho echazwe kulesi sihloko esifushane.
Ngezansi kunezindatshana ezikhuluma ngokuthi kungani ukudla kwe-ketogenic, kanye nokulawulwa okulandelayo kwe-mitochondria okuphumela, kuyizindlela zokwelapha ezimangalisayo zokuxilonga okuhlukahlukene.
Uma ungakuboni ukuxilongwa ofisa ukufunda ngakho, vele uskrolele phansi kubha yokusesha ngezansi kwekhasi!
Manje njengoba usunombono ongcono weminye yemisebenzi ehlinzekwa yi-mitochondria, usesimweni esingcono kakhulu sokujabulela okuthunyelwe kwebhulogi kule webhusayithi.
Uma ungathanda ukuhlola uhlelo lwe-inthanethi ohambweni lwakho lokufunda zonke izindlela ongazizwa ungcono ngazo, ngikukhuthaza ukuthi ufunde kabanzi ngoHlelo lwami Lokubuyisela Inkungu Yengqondo.
Okubhekwayo
U-Anderson, AJ, Jackson, TD, Stroud, DA, & Stojanovski, D. (2019). I-Mitochondria-amahabhu okulawula i-biochemistry yamaselula: imiqondo evelayo namanethiwekhi. Vula ibhayoloji, 9(8), i-190126. https://doi.org/10.1098/rsob.190126
U-Bennett, JP (2019). I-hypothesis yezokwelapha: Izifo ze-neurodeergenerative zivela emonakalweni we-oxidative kumaprotheni e-electron tunneling ku-mitochondria. Ama-Hypotheses Wezokwelapha, 127, 1-4. https://doi.org/10.1016/j.mehy.2019.03.034
Bennett, JP, & Onyango, IG (2021). Amandla, i-Entropy kanye ne-Quantum Tunneling yama-Proton kanye nama-Electron ku-Brain Mitochondria: Ukuhlobana Nokukhubazeka Kwe-Mitochondrial Ezifweni Zobuchopho Zomuntu Ezihlobene Nokuguga kanye Nezinyathelo Zokwelapha. Ama-Biomedicines, 9(2), Isigaba 2. https://doi.org/10.3390/biomedicines9020225
U-Dzeja, PP, Bortolon, R., Perez-Terzic, C., Holmuhamedov, EL, & Terzic, A. (2002). Ukuxhumana okunamandla phakathi kwe-mitochondria ne-nucleus eqondiswa yi-catalyzed phosphotransfer. Izinqubo ze-National Academy of Sciences, 99(15), i-10156-10161. https://doi.org/10.1073/pnas.152259999
Kanellopoulos, AK, Mariano, V., Spinazzi, M., Woo, YJ, McLean, C., Pech, U., Li, KW, Armstrong, JD, Giangrande, A., Callaerts, P., Smit, AB, Abrahams, BS, Fiala, A., Achsel, T., & Bagni, C. (2020). I-Aralar Sequesters GABA ibe yi-Hyperactive Mitochondria, Idala Ukusilela Kokuziphatha Komphakathi. Iseli, 180(6), 1178-1197.e20. https://doi.org/10.1016/j.cell.2020.02.044
Ingqondo ye-Metabolic (Umqondisi). (2022, Novemba 30). I-Mitochondria ebuchosheni naseMzimbeni-Martin Picard PhD. https://www.youtube.com/watch?v=u51JSv4AK-0
U-Palmer, C. (2022). Amandla Obuchopho (uhlelo loku-1). https://a.co/d/hKy6x2A
Picard, M., Zhang, J., Hancock, S., Derbeneva, O., Golhar, R., Golik, P., O'Hearn, S., Levy, S., Potluri, P., Lvova, M ., Davila, A., Lin, CS, Perin, JC, Rappaport, EF, Hakonarson, H., Trounce, IA, Procaccio, V., & Wallace, DC (2014). Ukwanda okuqhubekayo kwe-mtDNA 3243A>G heteroplasmy kubangela ukuhlelwa kabusha kwe-transcriptional kungazelelwe. Izinqubo ze-National Academy of Sciences, 111(38), E4033–E4042. https://doi.org/10.1073/pnas.1414028111
Safiulina, D., & Kaasik, A. (2013). I-Energetic and Dynamic: I-Mitochondria Ihlangabezana Kanjani Nezidingo Ze-Neuronal Energy. I-PLOS Biology, 11(12), i-e1001755. https://doi.org/10.1371/journal.pbio.1001755
Spinelli, JB, & Haigis, MC (2018). Iminikelo Ehlukahlukene Ye-Mitochondria ku-Metabolism Yeselula. I-Nature Cell Biology, 20(7), i-745-754. https://doi.org/10.1038/s41556-018-0124-1
I-West, AP, Shadel, GS, & Ghosh, S. (2011). I-Mitochondria ekuphenduleni kwamasosha omzimba okuzalwa. Ukuhlolwa Kwemvelo Ukuzivikela Komzimba, 11(6), Isigaba 6. https://doi.org/10.1038/nri2975
Zhu, X.-H., Qiao, H., Du, F., Xiong, Q., Liu, X., Zhang, X., Ugurbil, K., & Chen, W. (2012). Ukucabanga okulinganiselwe kwezindleko zamandla ebuchosheni bomuntu. I-NeuroImage, 60(4), i-2107-2117. https://doi.org/10.1016/j.neuroimage.2012.02.013
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