Ukwelashwa Okungcono Kakhulu kwe-COVID Brain Fog
Isikhathi sokufunda esilinganiselwe: 20 imizuzu
Olunye ucwaningo olusha luphumile luhlola ukuvela kwezimpawu zemizwa kubantu abangenwe yi-COVID. Bathole ukuthi kulabo abangenwe yi-COVID (eyokuqala, hhayi okuhlukile), kube namathuba angama-42% anda okuba nezinkinga zemizwa.
Futhi enye yalezo ezikhonjwe inkungu yobuchopho. Futhi abanye benu bahlushwa inkungu yobuchopho osola ukuthi ivela ekuthelelekeni kwe-COVID okwedlule (okuhlukile noma cha). Futhi uyazibuza ukuthi yini ongayenza ngakho, unganciphisa kanjani izimpawu zakho zenkungu yobuchopho, futhi wenze lula ukuphulukiswa.
Uma ubulokhu uhlushwa inkungu yobuchopho ephindaphindayo noma ebeleselayo kusukela ekuthelelekeni kwakho kwe-Covid, ngifuna wazi ukuthi awuwedwa.
Ukuntuleka kokuqonda kwengqondo kuye kwachazwa ngokwandayo ezincwadini njengokuthi “inkungu yobuchopho” ... Nakuba kungakabi khona ukuvumelana mayelana nendlela yokuchaza leli gama, ukulahlekelwa inkumbulo, ukungagxili kahle, ukugxilisa ingqondo okuncishisiwe, ukubambezeleka kokuthola amagama okwandisiwe, ubunzima bokulandelela ulwazi oluyinkimbinkimbi. , kanye nokuncipha kwemisebenzi yokuphatha konke kuhlotshaniswe naleli gama.
Rivas-Vazquez, RA, Rey, G., Quintana, A., & Rivas-Vazquez, AA (2022). Ukuhlolwa Nokuphathwa Kwe-COVID ende. Ijenali ye-Health Service Psychology, 48(1), i-21-30. https://link.springer.com/article/10.1007/s42843-022-00055-8
Futhi ngenxa yokuthi ngimayelana nawe ngazi zonke izindlela ongazizwa ungcono ngazo, ngizonikela ngalokhu okuthunyelwe ngikubonise ukuthi kungani ukudla okune-ketogenic kuyisinyathelo sokuqala esisekelwe ebufakazini ekuhlinzekeni ukwelashwa okunamandla kwezimpawu zenkungu yobuchopho obuhlobene ne-COVID.
Izifundo engizibhekile (bheka izikhombo ekugcineni kwesihloko) zixoxe ngokuthi iningi ledatha livela kubantu abaneminyaka engaphezu kwengama-60 nokuthi labo abalaliswe esibhedlela ngokuvamile baba nezinkinga ezinkulu zemizwa ngemva kwalokho. Kodwa njengomuntu osiza abantu ngobuchopho babo futhi okhuthele ezinkundleni ezihlukahlukene, ngingakuqinisekisa ukuthi okuningi kokuthunyelwe-I-COVID yobuchopho inkungu unolwazi kuwo wonke amaqembu eminyaka. Futhi yilokho abakuthola kulawa maphepha ahlola izinombolo. Ngisho nabantu abanezifo ezincane bangaqhubeka nokuthuthukisa izinkinga zemizwa. Akukho okuhlangenwe nakho kokulaliswa esibhedlela okubonisa ukuqina okubonakala kudingekile.
Ukubonakaliswa okuvamile kwemizwa 'ye-COVID-ende' kuhlanganisa ukukhathala; 'inkungu yobuchopho'; ikhanda elibuhlungu; ukukhubazeka kwengqondo; ukulala, imizwa, iphunga, noma ukuphazamiseka kokunambitha; i-myalgias; ukuntuleka kwe-sensorimotor; kanye ne-dysautonomia.
Ukubonakaliswa okuvamile kwemizwa 'ye-COVID-ende' kuhlanganisa ukukhathala; 'inkungu yobuchopho'; ikhanda elibuhlungu; ukukhubazeka kwengqondo; ukulala, imizwa, iphunga, noma ukuphazamiseka kokunambitha; i-myalgias; ukuntuleka kwe-sensorimotor; kanye ne-dysautonomia.
https://doi.org/10.1177/20406223221076890
Futhi kulabo abahluphekayo, kuyinto ethusayo futhi eqeda amandla, enokusekelwa okuncane okutholakala ngendlela yemithi noma imithi yokwelapha ukuze kudambise izimpawu.
Futhi nakuba lokho kungase kushintshe esikhathini esizayo, abaningi benu bayahlupheka manje. Futhi ngifuna wazi ukuthi izindlela zokwelapha ezisebenzayo zikhona kusetshenziswa izindlela zokwelapha ubuchopho be-metabolic njengokudla kwe-ketogenic.
Iziphi izinhlobo zezinkinga zemizwa esizibonayo nge-COVID ende ehambisana ngqo nenkungu yobuchopho noma esivame ukuzithola zenzeka kanye nezimpawu zenkungu yobuchopho?
- Ukuphazamiseka kwengqondo kanye nenkumbulo
- Izinhlungu zekhanda ze-Episodic ngisho ne-migraines
- Impilo yengqondo - ingcindezi nokuphazamiseka kokulungisa, ukuphazamiseka kokukhathazeka, ukuphazamiseka okukhulu kokucindezeleka, nokuphazamiseka kwengqondo
Ngakho-ke ukudla kwe-ketogenic kungasiza kanjani kulezi zinkinga ezingathi sína zemizwa ezilethwa ukutheleleka kwe-Covid?
Ukudla kwe-ketogenic kuvumela umzimba ukuthi ukhiqize ama-ketones. Futhi ama-ketone ayizindikimba ezibonisa amangqamuzana ezithonya ukubonakaliswa kofuzo. Futhi isisho sofuzo esinikezayo singathuthukisa ukubonakaliswa kwamandla obuchopho ku-hypometabolic (ukusetshenziswa kwamandla aphansi) izakhiwo, ukunciphisa i-neuroinflammation kanye nokucindezeleka okwenziwe nge-oxidative, futhi kuthuthukise ibhalansi ye-neurotransmitter.
Lezi zinto zihlangene ngani ne-Covid ende? Konke. Sibona izinkinga ngalezi zici ezine ku-Covid ende, futhi ikakhulukazi ngezimpawu zemizwa ezibonakala ngenxa yokutheleleka kwangaphambili kwe-Covid.
Ake sihlole izincwadi.
I-Brain Hypometabolism kanye ne-Covid Brain Fog
Izindawo ze-hypometabolism yobuchopho zenzeka futhi zingaphikelela ngemva kokutheleleka nge-Covid. I-Hypometabolism yigama elisetshenziselwa ukuchaza ukungakwazi noma ikhono elikhubazekile lokukhiqiza amandla (hypo=low, metabolism=indalo yamandla). Abantu abahlushwa izimpawu ze-Covid ezinde babonakale benezindawo eziqhubekayo ze-hypometabolism ku-frontoparietal lobes yesikhashana, okubonakale sengathi yaba ngcono ngemuva kwezinyanga eziyi-6 kusukela ekuqaleni kwezimpawu.
Okuhle. Kuhle ukuthi i-hypometabolism ebonwe ngemuva kwe-Covid kucatshangwa ukuthi izoxazululwa ekugcineni. Kodwa nansi into. Ukuqubuka kwe-hypometabolism yobuchopho yesikhathi eside kuyinhlekelele. Ngenkathi ubuchopho bakho budonsa kanzima ukusebenzisa amandla kulezo zindawo, ukucindezeleka okwenziwe nge-oxidative kuyenyuka, futhi uma kunzima ngokwanele, izakhiwo zizoncipha. Kukhona ingozi yokulahlekelwa grey (ubuchopho). Akukuzuzisa kakhulu ukuthi “ulinde” ukuze lezo zingxenye zobuchopho ziphinde zikhanyise futhi ukwazi ukusebenzisa amandla kahle futhi. Udinga ukuhlenga amandla obuchopho MANJE!
Izinguquko ezengeziwe ezingaguquguquki zibandakanya ukungahambi kahle kokusebenza nesakhiwo ku-insula kanye ne-parahippocampus.
U-Najt, P., Richards, HL, & Fortune, DG (2021). Ukuthwebula ubuchopho ezigulini ezine-COVID-19: Ukubuyekezwa okuhlelekile. Ingqondo, ukuziphatha, kanye ne-immunity-impilo, 16, 100290.
Lokhu kuyinkinga. Nakuba izinguquko eziphikelela kakhulu zibonwe ezindaweni zokuhogela zobuchopho, asikwazi ukuziba izinguquko eziqhubekayo ezibonwa ku-insula kanye ne-parahippocampus. Zombili ziyizakhiwo ezibalulekile ekuqondeni nasekukhumbuleni.
Indawo eyengeziwe ye-hypometabolism eqhubekayo i-fronto-insular cortex. Le ndawo yobuchopho iqukethe amanethiwekhi abalulekile okuxhumana ayingxenye yekhono lokulawula ingqondo. Lokhu kubukeka njengekhono lokushintsha ukunaka, ukubamba ukunaka, ukubuyisela ukunaka emsebenzini, futhi ngokuvamile ukwazi ukugxila. Lezi yizikhalazo esizizwa abantu abanenkungu yobuchopho be-COVID bekhalaza njalo. Ngakho-ke, ngingaphakamisa ukuthi i-hypometabolism yobuchopho okuhlangenwe nakho kufanele kube iphuzu eliyinhloko lokungenelela.
Kunenkinga emandleni obuchopho ngemva kokutheleleka nge-Covid. Kubhalwe kahle ukuthi i-SARS-COV2 idala ukungasebenzi kahle kwe-mitochondrial futhi ingaphansi kwe-neuropathy eqhubekayo ebonwa kwabanye abantu abanezimpawu ze-Covid ende.
Ngenhlanhla, isayensi inokungenelela okhulula amandla obuchopho. Kokubili ngokunikeza omunye umthombo wamafutha kanye nokuthuthukisa inombolo ye-mitochondrial kanye nomsebenzi.
Izidlo ze-Ketogenic ze-hypometabolism yobuchopho kanye nokungasebenzi kahle kwe-mitochondrial okubonwe ku-Covid yobuchopho inkungu
Izidlo ze-Ketogenic zisetshenziselwa ngokukhethekile ukuthuthukisa i-hypometabolism yobuchopho kubantu abahlukahlukene. Ukusetshenziswa okuvame kakhulu ngesifo i-Alzheimer's, lapho izinhlaka zobuchopho ezibalulekile zingasakwazi ukusebenzisa i-glucose ukuze zithole uphethiloli ngempumelelo. Lokhu kubangela ukuthi izindawo zobuchopho zilambe ngokoqobo futhi kwandisa ingcindezi ye-oxidative, okubangela ukuwohloka okwengeziwe. Izidlo ze-ketogenic ziwonga kanjani amandla obuchopho? Ngokunikeza omunye umthombo wamafutha. Ukudla kwe-Ketogenic kukhiqiza ama-ketones, okuwumthombo wamafutha okhethwayo wobuchopho. Bangakwazi ukudlula imishini ephukile edingekayo ukuze kungene i-glucose futhi bamuncwe ngokuqondile kuseli futhi basetshenziswe amabhethri eseli (mitochondria), umthombo wamafutha ophakeme.
Angiwabizi njengomthombo wamafutha ophakeme kalula. Ngenxa yokuthi ama-ketone awawona nje umthombo kaphethiloli, ayimizimba yamangqamuzana ebonisa izimpawu enemiphumela enamandla, enezici eziningi ukukhuthaza amandla obuchopho. Ama-ketones azokwenza izinguquko ezizokwandisa inombolo, impilo, nokusebenza kahle kwe-mitochondria ekhona (ama-cell powerhouses) ahlinzeka ngamandla.
Ngakho-ke njengabantu abanesifo i-Alzheimer's esithambile kuya kokulinganisela, ukudla okune-ketogenic kungahlenga izindawo ze-hypometabolism yobuchopho futhi kwandise amandla obuchopho ngokusebenza okuthuthukisiwe kwe-mitochondrial. Futhi asikho isizathu sokukholelwa ukuthi bebengeke bafeze insizakalo efanayo ezindaweni ze-hypometabolism yobuchopho ngenxa ye-Covid. Futhi asikho isizathu sokukholelwa ukuthi ukudla kwe-ketogenic ngeke kukwazi ukwenza ngcono ukungasebenzi kahle kwe-mitochondrial okubhalwe kahle ezincwadini zesayensi ezishiwo yi-Covid. Eqinisweni, ngaphandle kwamandla obuchopho athuthukisiwe, lawo mangqamuzana awakwazi ukwenza umsebenzi wokulungisa lezo zakhiwo futhi akhe kabusha.
Ukwehla kwamandla obuchopho okuvela ekusebenzeni kabi kwe-mitochondrial kanye nezindawo ze-hypometabolism yobuchopho kubangela ton ukucindezeleka kwe-oxidative. Ngakho-ke akumangazi ukuthi ingcindezi ye-oxidative nayo ibonakala iyinkinga nge-Covid ende.
Lokhu kusiletha esigabeni sethu esilandelayo.
I-Oxidative Stress kanye ne-Covid brain fog
Akukho mbuzo noma impikiswano mayelana nokuthi siyayibona ingcindezi ye-oxidative ezigulini ezinde ze-Covid.
Izinqubo ze-neuroinflammatory kanye ne-oxidative stress kucatshangwa ukuthi zihamba phambili ekusakazeni ukulandelana kwe-neurological 'long-COVID'
UStefanou, MI, Palaiodimou, L., Bakola, E., Smyrnis, N., Papadopoulou, M., Paraskevas, GP, … & Tsivgoulis, G. (2022). Ukubonakaliswa kwe-Neurological of long-COVID syndrome: Ukubuyekezwa okulandisayo. Intuthuko yokwelapha ezifweni ezingapheli, 13, 20406223221076890.
I-oxidative stress yigama elisetshenziselwa ukuchaza ukungalingani phakathi kwenani lomonakalo okwenzeka kuseli kanye nekhono lomzimba lokulwa nakho futhi ukwazi ukuhambisana nokulungisa. Kucatshangwa ukuthi ukucindezeleka okwenziwe nge-oxidative kungase kube nesibopho sokungasebenzi kahle kwe-endothelial kanye ne-vascular esikubona kwenzeka ngemva kokutheleleka kuze kube yizinyanga ezingu-4 ngemuva (futhi abaningi benu bazobe behlangabezane nalokhu isikhathi eside nakakhulu). Ingcindezi ye-oxidative ifana neqembu elihlanzayo elinenani elincane kakhulu futhi elingenazo izinto zokuhlanza ezanele ukuba zihambe. Abakwazi ukwenza umsebenzi. Futhi ingqondo yakho ayilungiseki. Futhi lokhu kubangela umjikelezo womonakalo owengeziwe ongalungiseki. Futhi ngicabanga ukuthi uyawuthola umqondo.
Ukubhekana nengcindezi ye-oxidative eyingxenye yenkungu yobuchopho ye-Covid ende kudinga ukuba yindawo yokuqala yokugxila.
Ingcindezi ye-oxidative ku-Covid brain fog kanye nokudla kwe-ketogenic
Ngakho-ke ukudla kwe-ketogenic kusiza kanjani ukunciphisa ukucindezeleka okwenziwe nge-oxidative? Izindlela eziningi. Ukushiswa kwama-ketones kuphethiloli kunikeza amandla ahlanzekile ngemikhiqizo embalwa okufanele ihlanzwe. Kodwa ikakhulukazi, ngicabanga ukuthi indawo emnandi isemandleni ayo okulawula ukukhiqizwa kwezinhlelo ze-antioxidant ezingapheli. Ikakhulukazi, ukukhiqizwa kwe-glutathione eyengeziwe.
Ukukhiqizwa kwe-glutathione kubalulekile. Futhi izakhiwo ze-molecule ezibonisa ama-ketone zisiza umzimba wakho ukwenza okuningi. Futhi uma unezimpawu zenkungu yobuchopho, kungakhathaliseki ukuthi kungani, i-glutathione empeleni ingumngane wakho omkhulu kanye nengxenye yokubambisana ekululameni kwakho.
Uma une-Covid ende ebonakale njengezimpawu zenkungu yobuchopho, kungenzeka ukuthi usungule umgoqo ovuzayo wegazi nobuchopho. Lokho kusho ukuthi izinto ziyasondela ebuchosheni bakho okungafanele ukuthi zibe phezulu lapho, okubangela ukuthi amasosha omzimba akho axakeke futhi abe nomthelela ku-neuroinflammation ngokukhiqizwa kwama-cytokines avuvukalayo.
Kwakufanele ube nesivimbelo esinempilo sobuchopho-gazi ukuze ungangeni. Kepha ukutheleleka kwakho kwe-Covid kungenzeka kwenze lokho kungenzeki, futhi kusengazama ukulungisa (kodwa ukuntula amandla obuchopho, ama-micronutrients anele, kanye nokuhlasela kwengcindezi ye-oxidative okunganqamuki, ngeke kwenzeke).
Ngenhlanhla, izidlo ze-ketogenic zinhle kakhulu ekuvimbeleni ubuqotho besithiyo segazi. Ngibhale ngakho lapha kulesi sihloko ngezansi:
I-Glutathione isetshenziselwa ukusiza ukulungisa lesi sivimbelo, futhi isetshenziselwa ukusiza ukulungisa umonakalo. Futhi angikwazi ukucabanga ngesimo lapho ukulawulwa kokukhiqizwa kwe-glutathione kungeke kube ukubaluleka kwezinkanyezi futhi kuzuze umuntu onenkinga yezimpawu zenkungu yobuchopho ende ye-Covid.
I-Neuroinflammation kanye ne-Covid Brain Fog
Akudingeki ukuthi uthole inkontileka ye-Covid ukuze wazi ukuthi ama-cytokines avuvukalayo azizwa kanjani ebuchosheni bakho. Noma ubani owehliswe umkhuhlane omubi kakhulu noma ngisho nomkhuhlane uyazi ukuthi ukhathala kangakanani. Uvele uhlale noma ulale, futhi awusavuki futhi uze uzizwe ungcono. Ubuchopho bakho abusebenzi kahle, futhi awulokothi usondele kunoma yini lapho kudingeka khona ukunemba noma ukugxila. Futhi ngokungagwegwesi, awunaso ngisho nogqozi lokuzama! Uvula imuvi yakho oyithandayo bese ulala nekati lakho uze uzizwe ungcono (Kulungile, yimina lowo, kodwa cishe wenza okufanayo). Lokhu ukuziphatha kokugula okuqalwa ama-cytokine avuvukalayo ebuchosheni bakho.
Ama-cytokines avuthayo ebuchosheni ayingxenye edingekayo yokululama. Kodwa kunezimo nakanjani lapho inqubo yokuvuvukala iqala khona futhi ayikwazi ukuzola futhi ivele iqhubeke ingalawuleki. I-Traumatic Brain Injury (TBI) iyisibonelo esihle salokhu, njengezifo ezithile. Lokhu kungenzeka futhi uma amasosha akho omzimba engalingani futhi esebenza kahle.
Ngakho-ke uma ungitshela ukuthi usahlangabezana nemikhuba yokugula ngemuva kokutheleleka nge-Covid, ngiyakukholwa.
Kanjalo nezincwadi zocwaningo.
Isiphepho se-cytokine esivuvukalayo sonke esizwile ngaso sandisa i-neuroinflammation, ebuye ikhiqize ingcindezi enkulu ye-oxidative. Khumbula, ngemva kokuvuvukala kudingeka kube neqembu lokuhlanza. Lokhu kuholela ekusakazekeni kwenqubo ye-neuroinflammatory.
Futhi abantu abaningi ababekezelele ukutheleleka nge-Covid babeza kuyo kakade ne-neuroinflammation engelashiwe ngenxa yesifo sendlela yokuphila, isimo esingesihle noma esinganele somsoco, noma okunye ububi obungenza kube nzima ukudambisa inqubo ye-neuroinflammatory ibuyele phansi.
Bekungadingeki ube “nesivunguvungu” ukuze udale inqubo yokuvuvukala kwemithambo-luvo enenkinga yokuzola ngokwayo. Iningi labantu abanamacala athathwa njenge-Covid emnene bahlushwa inkungu yobuchopho.
Ngakho udinga ukungenelela okunamandla ukunciphisa ukuvuvukala. Futhi ukungenelela okunamandla kakhulu ukunciphisa ukuvuvukala (kanye ne-neuroinflammation ikakhulukazi) engikwaziyo ukudla kwe-ketogenic. Ake ngikutshele ukuthi isebenza kanjani.
Ukudla kwe-Ketogenic kanye ne-Covid brain fog neuroinflammation
Ukudla kwe-ketogenic kudala imizimba ye-ketone. Enye yaleyo mizimba ye-ketone ibizwa ngokuthi i-beta-hydroxybutyrate (BHB). I-BHB iyingqamuzana ebonisa amangqamuzana, futhi lokhu kusho ukuthi inamandla ngokwanele ukuvala nokuvula ukubonakaliswa kofuzo. Esinye sezici zemilingo ze-BHB yikhono layo lokwenqaba ukubonakaliswa kofuzo okungapheli. Usathola impendulo eqinile yokuvuvukala esebenza kahle, njengoba uzoyidinga uma ushaya i-shin yakho ohlakeni lombhede noma uzisika ngenkathi ulungiselela isidlo sakusihlwa. Kodwa ivala futhi idambise izakhi zofuzo ezivulayo futhi zisize futhi zigcine impendulo yokuvuvukala okungapheli.
Futhi uma usebenzelana nenkungu yobuchopho ngemuva kwe-Covid, ukudinga ngempela lokho.
I-Neurotransmitter Ukungalingani kanye ne-Covid
Ngokuvamile, lapho ngibhala mayelana nokudla kwe-ketogenic kanye nebhalansi ye-neurotransmitter, ngibhala ngemiphumela yabo ku-serotonin, i-dopamine, i-norepinephrine, i-GABA, ne-glutamate. Kuningi ngempela okuthunyelwe kwebhulogi kule sayithi mayelana nemiphumela yalawo ma-neurotransmitters. Ungenza ukusesha kunoma iyiphi yazo emugqeni wokusesha phansi impela kwalesi sihloko futhi ufunde kabanzi!
Kodwa ngenxa yokuthi lokhu okuthunyelwe kumayelana ne-Covid ngokuqondile, sizocwila kakhulu ku-Nitric Oxide (NO), engacatshangwa njenge-neurotransmitter ebuyisela emuva.
I-Nitric Oxide (NO) kanye ne-enzyme ehambisana nayo eyikhiqizayo (i-Nitric Oxide Synthase) ibaluleke kakhulu futhi yenza izinto eziningi ezibalulekile ukusiza ukulawula zona kanye izimpawu abantu abane-Covid ende abavame ukukhononda ngazo. Kuyasiza ukulawula ubuhlungu, umsebenzi we-neuroendocrine, kanye ne-HHP Axis (i-hypothalamus-hypophysis axis) elawula impendulo yokucindezeleka, isimiso somzimba sokuzivikela ezifweni, isimo sengqondo, ukulala, kanye nomsebenzi we-hippocampal (inkumbulo).
Futhi mhlawumbe okuhlaba umxhwele kakhulu futhi okungase kubaluleke kakhulu ukuthi i-Nitric Oxide (NO) iphazamisa ukuhlangana kweplatelet. I-Platelet aggregation inqubo lapho ama-platelet anamathelana endaweni yokulimala kwemithambo.
Lokhu kungaba usizo uma sikhuluma ngokunciphisa izehlakalo zokushaywa unhlangothi.
Eqinisweni, ngemva kokutheleleka nge-Covid, umzimba wakho uzama ukukhiqiza i-nitric oxide eyengeziwe ukusiza ukuphulukisa umonakalo.
Ngemuva kokutheleleka kwe-SARS-CoV-2, i-mitochondria ekwazi ukuthwala igazi ihlinzeka ngomthombo wenoveli we-ATP yokubuyisela kanye ne-constitutive nitric oxide synthase (cNOS) ukukhuthaza ukukhishwa kwe-nitric oxide (NO), eqeda ukuvuvukala.
UStefano, GB, Büttiker, P., Weissenberger, S., Martin, A., Ptacek, R., & Kream, RM (2021). I-pathogenesis ye-COVID-19 ye-neuropsychiatric yesikhathi eside kanye nendima ye-microglia, mitochondria, kanye ne-neuroinflammation eqhubekayo: i-hypothesis. I-Medical Science Monitor: Ijenali Yezokwelapha Yamazwe Ngamazwe Yocwaningo Lokuhlola Nokwelashwa, 27, e933015-1.
Siphakamisa ukuthi ezinye zezimpawu ze-neurological ezigulini ezine-COVID-19 zihlotshaniswa nokwehla okubangelwa yigciwane kumazinga e-NO ebuchosheni.
U-Annweiler, C., Bourgeais, A., Faucon, E., Cao, Z., Wu, Y., & Sabatier, JM (2020). I-Neurological, Cognitive, and Behavioral Disorders ngesikhathi se-COVID-19: The Nitric Oxide Track. Ijenali ye-American Geriatrics Society. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7361837/
Bekungeke yini kube kuhle uma bekukhona indlela yokuthuthukisa ukukhiqizwa kwakho kwe-nitric oxide ukuze ukwazi ukusiza ukwelapha ubuchopho bakho?
Ukuvivinya umzimba kwandisa i-nitric oxide, kodwa ngiyazi ukuthi abanye benu bahlushwa ukungabekezeleli ukuzivocavoca mhlawumbe ngenxa yokukhathala okungapheli okuba khona noma uthola ukuphelelwa umoya kalula njengengxenye yezimpawu zakho ze-Covid ende. Ngakho-ke ngeke nginitshele ukuthi phumani niyozivocavoca ngoba abanye benu abakwazi.
Ngenhlanhla, kunenye indlela enamandla yokwandisa ukukhiqizwa kwe-Nitric Oxide (NO). Ukuqagele. Ukudla kwe-ketogenic!
Ukudla kwe-Ketogenic kanye nebhalansi ye-neurotransmitter - imiphumela ku-Nitric Oxide kanye nokwelashwa okungenzeka kwe-Covid yobuchopho
Izidlo ze-Ketogenic zithuthukisa ukusebenza kwe-neurovascular, ikakhulukazi ngokwenza lula ukukhiqizwa kwe-Nitric Oxide (NO). Eqinisweni, abacwaningi bakhuluma ngokuthi ukusebenzisa ukudla kwe-ketogenic ekuqaleni kokuncipha kwengqondo kunganciphisa ingozi yesifo i-Alzheimer's, ngokwengxenye ngenxa yomsebenzi owenziwe ngcono wemithambo yobuchopho obonwayo. Futhi kukhona ucwaningo lokuphakamisa ukuthi ukudla kwe-ketogenic kwandisa ngokuqondile ukukhiqizwa AKUKHO ezakhiweni ezibalulekile ezidingekayo ukuze kukhunjulwe, njenge-hippocampus. Futhi angazi noma ubani okhala ngenkungu yobuchopho engakhonondi ngezinga elithile ngokuncipha kokusebenza kwenkumbulo.
Kodwa izimpawu zami ikakhulukazi ukukhathazeka nokucindezeleka!
Kulungile. Ubuchopho obunempilo buwubuchopho obunempilo. Uma ukholelwa ukuthi izimpawu zakho zenkungu yobuchopho ezivela ku-Covid ende zibangelwa kakhulu ukuphazamiseka kwemizwelo okuvele ngenxa yalokho, ukudla okune-ketogenic kusazoba ukwelashwa okunamandla kwezindlela ezikhona ezihilelekile.
Ungafunda kabanzi mayelana nokuthi ukudla kwe-ketogenic kungaba kanjani ukwelashwa okuyinhloko kokuphazamiseka kwemizwelo njengokukhathazeka nokudangala. Ungase uthande ukuqala ngokuhlola lezi zihloko ezingezansi:
Kodwa kuthiwani ngempilo yami yenhliziyo?!
Uma wesaba ukusebenzisa ukudla kwe-ketogenic ngoba wesaba amafutha agcwele, ngidinga ngempela ukuthi udlule kulokho. Akubhekwa njengokuma okusekelwe ebufakazini. Akekho umuntu obelokhu ehambisana nocwaningo ngalesi sihloko osakholelwa lokho. Futhi ukwehluleka kwalolo lwazi ukusabalalisa phansi emphakathini kungena endleleni yabantu abasebenzisa ukwelapha okunamandla okusekelwe ebufakazini njengokudla kwe-ketogenic ukuphulukisa izifo ezingapheli.
Ungathathi izwi lami ngakho. Ngimane nje ngingumelaphi wezempilo yengqondo onelayisensi enokuqeqeshwa okwengeziwe ekusebenziseni i-metabolic, umsoco, kanye nezindlela zokwelapha zengqondo ezisebenzayo. Angiyena udokotela wenhliziyo nanoma yini.
Kodwa laba bantu:
Benza ukubuyekezwa kwezincwadi zesayensi, futhi baphetha ngokulandelayo:
Ngakho-ke uma uhlushwa inkungu yobuchopho ephindaphindayo futhi engapheli ngenxa ye-Covid, sicela ucabangele ukudla okune-ketogenic. Futhi ungavumeli ukwesaba okungasekelwe futhi okungacwaningwe kahle kukuvimbele.
Isiphetho
Nansi into. Uma ungemva kwe-Covid futhi usahlushwa yinkungu yobuchopho, noma ngabe kuyinyanga kamuva noma ngisho neminyaka kamuva, angiqiniseki ukuthi udokotela wakho noma udokotela wakho wezinzwa usengakwazi ukukusiza ukuyelapha. Ukube bebekhona, ubungeke ube lapha ufunda lesi sihloko. Futhi awukwazi ukulinda kuze kube yilapho uthola ukuthi yiziphi izindlela zokwelapha ezisebenzayo ezizosiza. Odokotela nodokotela bezinzwa bangene shí ekhemisi njengokuyinhloko, futhi ngokungananazi, kuphela, ukungenelela kulokho obhekana nakho.
Kodwa asinalo iphilisi elilungisa i-hypometabolism yobuchopho, ingcindezi ye-oxidative, kanye ne-neuroinflammation. Futhi nakuba i-pharma ingazama ukuphikisa ukuthi kunemiyalelo yokungalingani kwe-neurotransmitter, leyo mithi ayikwenzi futhi ngeke ibhekane ne-hypometabolism yobuchopho, ukucindezeleka okwenziwe nge-oxidative, kanye ne-neuroinflammation engapheli.
I-Pharma izamile nemiyalelo yokulungisa lezi zinto ngaphandle kwempumelelo. Futhi lokho akungimangazi. Uyisistimu eyinkimbinkimbi futhi enhle. Ufanelwe olinganiselayo futhi i-pleiotropic ukungenelela. Okuyikho kanye ukudla kwe-ketogenic. Futhi ukudla kwe-ketogenic kuyatholakala kuwe manje.
Izidlo ze-Ketogenic, nama-ketones eziwakhiqizayo, zinezinzuzo ezengeziwe kubantu abaphethwe yi-Covid ende ezingaphezu kobubanzi balesi sihloko. Kubandakanya imiphumela enamandla yokulinganisa amasosha omzimba, izinguquko ezinhle ze-microbiome, kanye nokulungisa nokusebenza kwesithiyo sobuchopho segazi.
Sekuyisikhathi sokuthi ubuyisele ukusebenza kwakho kwe-neuro-cognitive futhi usebenzise ukungenelela okunamandla, okusekelwe ebufakazini bezinqubo eziyisisekelo ze-pathology esizibona zenzeka enkungu yobuchopho ende ye-Covid.
Ungafunda ngokuphelele indlela yokwenza ukudla kwe-ketogenic ukwelapha izinkinga zemizwelo nezengqondo ngezinsiza lapha kule bhulogi! Lokhu okuthunyelwe ngezansi kuyindawo enhle yokuqala.
Uma ungathanda usizo lokuqhubekela ekudleni kwe-ketogenic futhi ungathanda ukusebenzisa izindlela zokwelapha ezinomsoco ezengeziwe ezinamandla njengengxenye yokululama kwakho, ngikukhuthaza ukuthi uhlole Uhlelo lwami Lokubuyisela Inkungu Yengqondo. Kube yintokozo yami nenjabulo ukusiza abantu abaningi abaphethwe yi-Covid ende "ukubuyisela ubuchopho babo" ukuze baphile impilo yabo engcono kakhulu futhi baphumelele!
Kepha okubaluleke kakhulu, ngifuna nje ukuthi wazi ukuthi ukwelashwa okusekelwe ebufakazini bokungasebenzi kahle kwe-neurocognitive, ngisho nangemva kwegciwane elifana ne-Covid, likhona ngokuphelele. Futhi ukuthi uma udokotela wakho engazi okwanele ngabo ukuze asikisele kuwena, lokho akusho ukuthi kufanele uqhubeke uhlupheka kuyilapho uthola izincwadi. Ngifuna wazi zonke izindlela ongazizwa ungcono ngazo. Futhi lena enye yazo.
Okubhekwayo
Achanta, LB, & Rae, CD (2017). I-β-Hydroxybutyrate ebuchosheni: I-Molecule eyodwa, Izindlela Eziningi. Ucwaningo lwe-Neurochemical, 42(1), i-35-49. https://doi.org/10.1007/s11064-016-2099-2
U-Annweiler, C., Bourgeais, A., Faucon, E., Cao, Z., Wu, Y., & Sabatier, J. (2020). I-Neurological, Cognitive, and Behavioral Disorders ngesikhathi se-COVID-19: The Nitric Oxide Track. Ijenali ye-American Geriatrics Society, 68(9), i-1922-1923. https://doi.org/10.1111/jgs.16671
U-Cascella, M., & De Blasio, E. (2022). Izici nokuphathwa kwe-Acute and Chronic Neuro-Covid. I-Springer International Publishing. https://doi.org/10.1007/978-3-030-86705-8
Clough, E., Inigo, J., Chandra, D., Chaves, L., Reynolds, JL, Aalinkeel, R., Schwartz, SA, Khmaladze, A., & Mahajan, SD (2021). I-Mitochondrial Dynamics ku-SARS-COV2 Spike Protein Yelaphe i-Human Microglia: Imithelela Ye-Neuro-COVID. Ijenali ye-Neuroimmune Pharmacology, 16(4), i-770-784. https://doi.org/10.1007/s11481-021-10015-6
Incazelo ye-PLEIOTROPIC. (nd). Ibuyiselwe ngoSepthemba 30, 2022, kusukela https://www.merriam-webster.com/dictionary/pleiotropic
Förstermann, U., & Sessa, WC (2012). I-nitric oxide synthases: Umthetho kanye nomsebenzi. I-European Heart Journal, 33(7), i-829-837. https://doi.org/10.1093/eurheartj/ehr304
I-Gasquoine, PG (2014). Iminikelo ye-Insula ekuqondeni nasekuziphatheni. Ukubuyekezwa kwe-Neuropsychology, 24(2), i-77-87. https://doi.org/10.1007/s11065-014-9246-9
Goldberg, E., Podell, K., Sodickson, DK, & Fieremans, E. (2021). Ubuchopho ngemva kwe-COVID-19: I-neurogenesis enxephezela noma i-neuroinflammation eqhubekayo? Imithi ye-EClinical, 31. https://doi.org/10.1016/j.eclinm.2020.100684
Guedj, E., Campion, JY, Dudouet, P., Kaphan, E., Bregeon, F., Tissot-Dupont, H., Guis, S., Barthelemy, F., Habert, P., Ceccaldi, M. , Million, M., Raoult, D., Cammilleri, S., & Eldin, C. (2021). I-18F-FDG yobuchopho be-PET hypometabolism ezigulini ezine-COVID ende. I-European Journal of Nuclear Medicine kanye ne-Molecular Imaging, 48(9), i-2823-2833. https://doi.org/10.1007/s00259-021-05215-4
U-Hartman, AL, Gasior, M., Vining, EPG, & Rogawski, MA (2007). I-Neuropharmacology ye-Ketogenic Diet. I-Neurology Yezingane, 36(5), i-281. https://doi.org/10.1016/j.pediatrneurol.2007.02.008
Hone-Blanchet, A., Antal, B., McMahon, L., Lithen, A., Smith, NA, Stufflebeam, S., Yen, Y.-F., Lin, A., Jenkins, BG, Mujica- I-Parodi, LR, & Ratai, E.-M. (2022). Ukuphathwa okunamandla kwe-ketone beta-hydroxybutyrate kwehlisa amazinga e-7T proton magnetic resonance spectroscopy-derived of anterior and posterior cingulate GABA kanye ne-glutamate kubantu abadala abanempilo. I-Neuropsychopharmacology, 1-9. https://doi.org/10.1038/s41386-022-01364-8
I-JumpstartMD (Umqondisi). (2019, Januwari 30). UJohn Newman-Imizimba Ye-Ketone Njengama-Signaling molecule. https://www.youtube.com/watch?v=NmdBhwUEz9U
Kavanagh, E. (2022). Inkungu ende ye-Covid yobuchopho: i-neuroinflammation phenomenon? I-Oxford Open Immunology. https://doi.org/10.1093/oxfimm/iqac007
UKim, SW, Marosi, K., & Mattson, M. (2017). I-Ketone beta-hydroxybutyrate up-regulates BDNF expression ngokusebenzisa i-NF-κB njengempendulo eguquguqukayo ngokumelene ne-ROS, engase ithuthukise i-neuronal bioenergetics futhi ithuthukise i-neuroprotection (P3.090). Neurology, 88(16 Isengezo). https://n.neurology.org/content/88/16_Supplement/P3.090
U-Li, R., Zhang, S., Yin, S., Ren, W., He, R., & Li, J. (2018). I-fronto-insular cortex iyimbangela yokuxhumanisa imodi yokuzenzakalelayo kanye namanethiwekhi okuphatha amaphakathi ukuze abe negalelo ekusebenzeni kwengqondo komuntu ngamunye kwasebekhulile abanempilo. Ibalazwe le-Brain Mapping, 39(11), i-4302-4311. https://doi.org/10.1002/hbm.24247
Ma, D., Wang, AC, Parikh, I., Green, SJ, Hoffman, JD, Chlipala, G., Murphy, MP, Sokola, BS, Bauer, B., Hartz, AMS, & Lin, A.- L. (2018). Ukudla kwe-Ketogenic kuthuthukisa ukusebenza kwe-neurovascular nge-gut microbiome eguquliwe kumagundane amancane anempilo. Imibiko yeSayensi, 8(1), i-6670. https://doi.org/10.1038/s41598-018-25190-5
Martini, AL, Carli, G., Kiferle, L., Piersanti, P., Palumbo, P., Morbelli, S., Calcagni, ML, Perani, D., & Sestini, S. (2022). Ukululama okuncike ngesikhathi kwe-hypometabolism yobuchopho ezigulini ze-neuro-COVID-19. I-European Journal of Nuclear Medicine kanye ne-Molecular Imaging. https://doi.org/10.1007/s00259-022-05942-2
UMasino, SA (2022). Ukudla kwe-Ketogenic kanye Nokwelashwa Kwe-Metabolic: Izindima Ezandisiwe Kwezempilo Nezifo. I-Oxford University Press.
Menon, V., Gallardo, G., Pinsk, MA, Nguyen, V.-D., Li, J.-R., Cai, W., & Wassermann, D. (2020). Inhlangano ye-Microstructural ye-human insula ixhunywe kumjikelezo wayo womsebenzi omkhulu futhi ibikezela ukulawula kwengqondo. ELife, 9, e53470. https://doi.org/10.7554/eLife.53470
I-COVID emnene inyusa ubungozi bezinkinga eziningi zemizwa ezigidini. (2022, Septhemba 25). I-Atlas entsha. https://newatlas.com/health-wellbeing/mild-covid-risk-brain-neurological-problems/
U-Najt, P., Richards, HL, & Fortune, DG (2021). Ukuthwebula ubuchopho ezigulini ezine-COVID-19: Ukubuyekezwa okuhlelekile. Ubuchopho, Ukuziphatha, Nokuvikeleka - Impilo, 16, 100290. https://doi.org/10.1016/j.bbih.2021.100290
U-Newman, JC, & Verdin, E. (2017). I-β-Hydroxybutyrate: I-Metabolite Ebonisa izimpawu. Ukubuyekezwa Konyaka Kokudla Okunempilo, 37, 51. https://doi.org/10.1146/annurev-nutr-071816-064916
U-Noh, H., Kim, DW, Cho, G., & Choi, W. (2006). Ukwenyuka kwe-nitric oxide okubangelwa ukudla kwe-ketogenic kunciphisa isikhathi sokuqala sokubanjwa kwe-kainic acid-induced ku-ICR amagundane. Ucwaningo lweBongo, 1075, 193-200. https://doi.org/10.1016/j.brainres.2005.12.017
U-Noh, HS, Kim, DW, Cho, GJ, Choi, WS, & Kang, SS (2006). Ukwenyuka kwe-nitric oxide okubangelwa ukudla kwe-ketogenic kunciphisa isikhathi sokuqala sokubanjwa kwe-kainic acid-induced ku-ICR amagundane. Ucwaningo lweBongo, 1075(1), i-193-200. https://doi.org/10.1016/j.brainres.2005.12.017
Picón-Pagès, P., Garcia-Buendia, J., & Muñoz, FJ (2019). Imisebenzi kanye nokungasebenzi kahle kwe-nitric oxide ebuchosheni. I-Biochimica Et Biophysica Acta. Isisekelo samangqamuzana ezifo, 1865(8), i-1949-1967. https://doi.org/10.1016/j.bbadis.2018.11.007
Rivas-Vazquez, RA, Rey, G., Quintana, A., & Rivas-Vazquez, AA (2022). Ukuhlolwa Nokuphathwa Kwe-COVID ende. Ijenali ye-Health Service Psychology, 48(1), i-21-30. https://doi.org/10.1007/s42843-022-00055-8
Sauerwein, K. (2022a, Meyi 25). I-COVID ende ibeka engcupheni nakubantu abagonyiwe. I-Washington University School of Medicine e-St. https://medicine.wustl.edu/news/long-covid-19-poses-risks-to-vaccinated-people-too/
Sauerwein, K. (2022b, Septhemba 22). Izifo ze-COVID-19 zandisa ingozi yezinkinga zobuchopho zesikhathi eside. I-Washington University School of Medicine e-St. https://medicine.wustl.edu/news/covid-19-infections-increase-risk-of-long-term-brain-problems/
Shimazu, T., Hirschey, MD, Newman, J., He, W., Shirakawa, K., Le Moan, N., Grueter, CA, Lim, H., Saunders, LR, Stevens, RD, Newgard, CB , Farese, RV, de Cabo, R., Ulrich, S., Akassoglou, K., & Verdin, E. (2013). Ukucindezelwa kwe-Oxidative Stress nge-β-Hydroxybutyrate, i-Endogenous Histone Deacetylase Inhibitor. Isayensi, 339(6116), i-211-214. https://doi.org/10.1126/science.1227166
UStefano, GB, Büttiker, P., Weissenberger, S., Martin, A., Ptacek, R., & Kream, RM (2021). Umhleli: I-Pathogenesis ye-Long-Term Neuropsychiatric COVID-19 kanye Neqhaza le-Microglia, i-Mitochondria, kanye ne-Persistent Neuroinflammation: I-hypothesis. I-Medical Science Monitor : Ijenali Yezokwelapha Yamazwe Ngamazwe Yocwaningo Lokuhlola Nokwelashwa, 27, e933015-1-e933015-4. https://doi.org/10.12659/MSM.933015
Stefanou, M.-I., Palaiodimou, L., Bakola, E., Smyrnis, N., Papadopoulou, M., Paraskevas, GP, Rizos, E., Boutati, E., Grigoriadis, N., Krogias, C ., Giannopoulos, S., Tsiodras, S., Gaga, M., & Tsivgoulis, G. (2022). Ukubonakaliswa kwe-Neurological of long-COVID syndrome: Ukubuyekezwa okulandisayo. Intuthuko Yezokwelapha Ezifweni Ezingamahlalakhona, 13, 20406223221076890. https://doi.org/10.1177/20406223221076890
Valk, R., Hammill, J., & Grip, J. (2022). Amafutha agcwele: I-villain kanye ne-bogeyman ekuthuthukiseni isifo senhliziyo? I-European Journal ye-Cardiology Yokuvimbela, zwac194. https://doi.org/10.1093/eurjpc/zwac194
van Strien, NM, Cappaert, NLM, & Witter, MP (2009). I-anatomy yenkumbulo: Ukubuka konke okusebenzisanayo kwenethiwekhi ye-parahippocampal-hippocampal. Ukuhlolwa Kwemvelo Neuroscience, 10(4), i-272-282. https://doi.org/10.1038/nrn2614
U-Vanderheiden, A., & Klein, RS (2022). I-Neuroinflammation kanye ne-COVID-19. Umbono Wamanje ku-Neurobiology, 76, 102608. https://doi.org/10.1016/j.conb.2022.102608
U-Wang, Y., & Chi, H. (2022). Ukuzila ukudla njengethoni eyinhloko yokugonywa kwe-COVID. Uhlobo lweMetabolism, 1-3. https://doi.org/10.1038/s42255-022-00646-1
Warren, CE, Saito, ER, & Bikman, BT (nd). Ukudla Kwe-Ketogenic Kuthuthukisa Ukusebenza Kwe-Hippocampal Mitochondrial. 2.
U-Xu, E., Xie, Y., & Al-Aly, Z. (2022). Imiphumela yesikhathi eside ye-neurologic ye-COVID-19. Umuthi Wemvelo, 1-10. https://doi.org/10.1038/s41591-022-02001-z
Zhu, H., Bi, D., Zhang, Y., Kong, C., Du, J., Wu, X., Wei, Q., & Qin, H. (2022). Ukudla kwe-Ketogenic kwezifo zabantu: Izindlela eziyisisekelo kanye namandla okuqaliswa komtholampilo. Ukuguqulwa Kwesiginali kanye Nokwelashwa Okuhlosiwe, 7(1), i-1-21. https://doi.org/10.1038/s41392-021-00831-w