I-Neuroinflammation kanye nokucindezeleka
Ukuxhumana phakathi kokudangala kanye ne-neuroinflammation kuye kwafundwa iminyaka eminingi. Futhi nokho ukwelapha i-neuroinflammation ekucindezelekeni akucatshangwa njengento eyinhloko yokungenelela. Umphakathi wethu ulokhu uzama ukwelapha ukudangala ngemithi. Futhi nakuba zingasiza abantu abaningi, kunezibalo zabantu abaphethwe ukucindezeleka lapho imithi ingenele. Lokhu kubandakanya:
- Abantu abangaphenduli emuthini owodwa noma eminingi
- Abantu abasabela emithini kodwa okwesikhashana
- Abantu abasabela kancane kodwa abanezimpawu eziyinsalela abalashwanga kahle ngemithi yabo (Lena iningi leziguli)
- Abantu abasabelayo kodwa kufanele baphile nemiphumela engemihle eyehlisa izinga lempilo yabo
- Abantu abangakwazi ukubekezelela imiphumela emibi yemithi
Ngokucindezeleka okumaphakathi kuya kokulinganisela, impendulo emithini yengqondo iqhathaniswa ne-placebo.
Kuwukungahloniphi ukutshela laba bantu ukuthi impendulo yabo iwumuthi nje ohlukile. Kwabanye abantu, inketho yomuthi akuyona nje into enhle. Futhi lokhu kungenzeka ngoba imithi ayikwazi ukubhekana nembangela yokucindezeleka.
Ukucindezeleka kuyisifo se-neuroinflammation. Yebo, izakhi zofuzo zinengxenye ekucindezelekeni. Kodwa alukho ufuzo lokucindezeleka, futhi sithola ukuthi ingozi yokucindezeleka ibangelwa izici zemvelo. Lokhu kukhombisa ubungozi bofuzo esingakwehlisa ngokungenelela kwezemvelo. Ikhono lendawo yangaphakathi nengaphandle lokunquma indlela izakhi zofuzo eziziveza ngayo libizwa ngokuthi i-epigenetics.
Ukuvuvukala kuyimbangela evula izakhi zofuzo onazo ezikubeke phambili ekucindezelekeni.
Inqubo efanayo yokuvuvukala ebanga izifo emzimbeni wakho iyona ebangela ukuphazamiseka kwakho kwengqondo. Lokhu kuhlanganisa ukucindezeleka.
Ukuvuvukala kwenzeka lapho amasosha omzimba ekhiqiza ama-cytokines. Kunezinhlobo ezahlukene zama-cytokines. Lokhu kufaka kodwa akukhawulelwe ku-IL-1, IL-6, TNF-alpha, IFN-gamma. Lezi yizithunywa zamakhemikhali zamasosha omzimba. Ama-cytokines ajikelezayo ahambisana namazinga okukhathazeka, ukucindezeleka, nokukhubazeka kwengqondo. Lezi zonke izimpawu abantu abanokuhlangenwe nakho kokucindezeleka.
Amasosha omzimba asebenza ngokweqile enza ama-cytokines anomthelela ekucindezelekeni. Ama-Cytokines aphezulu kubantu abanokucindezeleka, futhi imithi yokucindezeleka ingase isebenze kangcono ngokunciphisa ama-cytokines avuthayo. Lokhu kuphambene nombono wokuthi indlela yokunciphisa izimpawu kuma-antidepressants ngokuyinhloko ukulungiswa kwe-neurotransmitter.
Ama-Cytokines enza i-enzyme ebizwa ngokuthi i-IDO (isikhashana). I-IDO iphula i-serotonin futhi yehlise i-tryptophan eyandulelayo. Lokhu kunciphisa ukutholakala kwe-serotonin neurotransmission kubantu abanokucindezeleka.
Lesi yisici esinamandla sezimpawu zokucindezeleka.
Pho kungani singaniki abantu abacindezelekile amaphilisi okulwa nokuvuvukala njenge-aspirin? Senza ngezinye izikhathi. Kukhona izinga lokuphendula eliphezulu uma sisebenzisa ama-antidepressants anedosi ephansi ye-aspirin. Kodwa uma usebenzisa ama-NSAID esikhundleni se-aspirin, yenza okuphambene. Ngakho-ke ungafaki inqwaba yama-NSAID ngethemba lokuthi kuzonciphisa ukucindezeleka.
Asiqageli lapha mayelana nokuvuvukala nokudangala. Uma sinikeza iziguli i-interferon (i-cytokine) ukwelapha ezinye izifo (isb, i-MS, i-hepatitis C), sibona imiphumela emibi yengqondo efana nokucindezeleka. Imiphumela engemihle esiyibona ngokwelashwa kwe-interferon ihlanganisa ukucabanga ukuzibulala, ukunganaki, ukungasebenzi kahle kwezocansi, ukuqwasha, ukucasuka, kanye nezinkinga zokuqonda.
Ingabe okunye kwalokhu okuzwakala kujwayelekile?
Ngiyabheja bayakwenza. Ingabe uyaqiniseka okwamanje ngokufana phakathi kwe-neuroinflammation nokucindezeleka?
Kuhle. Asiqhubeke.
Kungenzeka ukuthi uyabuza, kungani amasosha omzimba wami ethuka futhi ephule zona kanye lezo zinto engidinga ukuzizwa ngilungile? Kungani ingalandela i-serotonin precursor tryptophan (i-amino acid) uma icabanga ukuthi ngihlaselwa okuthile?
Ngoba amagciwane, njengama-microbes, adla i-tryptophan. Bayayithanda, futhi iyabasiza njengoba bezama ukuthelela amaseli akho. Ngakho-ke amasosha akho omzimba azama nje ukukubamba, futhi asuse into eyaziwa abantu ababi abazoyisebenzisa ukudala umonakalo. Kudela imizwa yakho ukuze usindise umzimba wakho. Ngakho-ke kufanele ubhekane nokuvuvukala. Noma amasosha akho omzimba ngeke azinze, futhi azoqhubeka nokuqoqa izinto ozidingayo ukwenza ama-neurotransmitters abalulekile njenge-serotonin.
Ake ngiphinde ngiyibhalele abantu abangemuva.
I-Neuroinflammation ingaba nendima eyimbangela ekucindezelekeni.
Ngakho-ke yiziphi izinhlobo zezinto ezibangela i-neuroinflammation?
- I-Standard American Diet (ushukela ophezulu, ama-carbohydrate agayiwe, uwoyela, amafutha e-trans)
- Ubuthi bemvelo njengama-herbicides, izibulala-zinambuzane, izinsimbi ezinzima
- Izifo ezingapheli zezinga eliphansi (isb, i-Lyme, isifo sezinsini, i-h. pylori, i-candida Albicans engapheli, i-Bora Virus, njll.)
- Ukwelashwa kokudla
- Ukungezwani nemvelo
- Ukungasebenzi kahle kokugaya ukudla (i-dysbiosis, i-IBS, njll.)
- Indlela yokuphila yama-sedentary
- Ukuntuleka kokudla okunomsoco
- Ukulala (okungabekwa phambili phambili noma ukuphazamiseka kokulala)
Esinye isici esinomthelela ku-neuroinflammation ukucindezeleka. Lesi ngesinye sezizathu ezenza ukuthi ezinye izindlela zokwelapha zengqondo zilungele ukudangala, ikakhulukazi izindlela zokwelapha zokuziphatha kwengqondo (CBT). I-CBT isiza amakhasimende ukuthi acubungule futhi ahlele kabusha izingcindezi zempilo ukuze angadali impendulo esheshayo yengcindezi. Lokhu kwehliswa kwengcindezi kungenxa yokukwazi kangcono ukuphatha izingcindezi zempilo. Lokhu kunciphisa isici esisodwa esikhulu sokuvuvukala.
Kodwa akuwona wonke umuntu ophendula i-CBT. Ngakho-ke asiqhubeke sifunda.
Uma ucindezeleka, kungakhathaliseki ukuthi kungenxa yokucindezeleka kwemvelo noma nje imicabango yakho ngalokho okwenzekayo, uthola ukuphakama kokuthile okubizwa ngokuthi i-glucocorticoids. Lokhu kuvuselela amasosha omzimba ebuchosheni bakho futhi kusebenze i-microglia. I-Microglia idlala indima enkulu esimisweni sokuzivikela komzimba sobuchopho bakho, futhi ikhipha inqwaba yama-cytokines. Osuvele wazi ukuthi kunomthelela ezimpawini zakho zokucindezeleka.
Udokotela wakho wengqondo cishe akakhulumi nawe nge-neuroinflammation njengembangela yokucindezeleka kwakho. Kungani? Ngoba kukhona ukunqanyulwa phakathi kwezincwadi zezemfundo osekuyiminyaka eminingi zifunda lesi sixhumanisi kanye nabasebenzi. Awukho umuthi omakethwayo we-neuroinflammation. Ukube bekukhona, udokotela wakho wengqondo cishe ubezokunikeza. Futhi bawuhlobo lokuzama ngokukunikeza ama-anti-depressants, anemiphumela yesikhashana eqeda ukuvuvukala. Eqinisweni, kunengxoxo yokuthi ukuncipha kwabo kwesikhashana kwe-neuroinflammation kungase kube isizathu esenza abanye abantu bathole ukukhululeka kwesikhashana kwezimpawu. Akuyona imiphumela ebikiwe ku-serotonin.
Uzodinga ukubhekana ne-neuroinflammation ngaphambi kokuthi uzizwe ungcono. I-SSRI ingase inciphise ukuvuvukala kancane, kodwa ayikwazi ukumisa i-microglia ekukhiqizeni ama-cytokines aqeda izinsiza ngendlela yezandulela zokwenza i-serotonin. Leyo SSRI igcina kuphela i-serotonin oyenza njengamanje kuma-synapse isikhathi eside.
I-Neuroinflammation iqeda izitolo zakho zomsoco, futhi udinga lezo zakhi ukuze wenze ama-neurotransmitters futhi ube namaseli obuchopho asebenza kahle. Uma ubuchopho bakho buhlala busebenzisa izinto ezisetshenziswayo ukuzama ukwakha kabusha umonakalo ovela ekucindezelekeni kwe-oxidative, khona-ke ibhalansi yakho ye-neurotransmitter izohlupheka. Iningi lalezo zakhi zomsoco ezidliwayo ekulweni nokuvuvuka yilokhu esikubiza ngama-rate-limiting factor. Lokhu kusho ukuthi uma ungenakho okwanele, awukwazi ukwenza ezinye izinto ozidingayo. Isikhathi.
Ngakho-ke ungabona ukuthi indlela yokwelapha kuphela ekucindezelekeni ayanele. Kumazinga amaningi. Ngakho-ke ake sikhulume ngokuthi ungathola kanjani imbangela yokuvuvukala kwakho, ukuze ukwazi ukwelapha izimpawu zakho zokucindezeleka.
Ukudla nokungezwani nemvelo
I-allergies yokudla iyisici esikhulu ekungasebenzi kahle kwamasosha omzimba. Ukusabela okuningi kwenzeka emaqandeni, amakinati, ubisi lwenkomo, amantongomane e-soy, i-shellfish, inhlanzi, nokolweni. Okuningi kwalokho kungenzeka ngenxa yempilo engeyinhle yamathumbu. Futhi ukulungisa ukudla kwakho kungaba yindlela enhle yokunciphisa ukuvuvukala. Ungase ungadingi ngisho nokukugwema ukudla unomphela. Uma ithumbu selipholile, ungathola ukuthi ungakwazi ukubuyisela ukudla okuningi obekuyinkinga phambilini. Ungasebenza nodokotela osebenzayo (uchwepheshe wezokudla okusebenzayo, udokotela wengqondo osebenzayo, umhlengikazi osebenza kahle, njll.) futhi angakusiza ukuthi uhlolele ukungezwani nokudla.
Izifo
Noma yikuphi ukutheleleka kungabangela ukuvuvukala. Lokhu kuhlanganisa ezingalapheki ezisezingeni eliphansi. Futhi hhayi ngisho nezinkulu ezesabekayo njengesifo seLyme. Ingabe unesikhunta sozwane esingamahlalakhona esingeke siphele? Lokho kungaba nomthelela ku-neuroinflammation yakho kanye nezimpawu zakho zokucindezeleka. Ukuthola ukuhlolwa okuthile kwemithi esebenzayo ngosizo lukadokotela kungaba usizo kakhulu ekuhlonzeni ukungalungi ukudla kanye nezifo eziwumshoshaphansi ezingase zibe nomthelela ku-neuroinflammation yakho.
Sleep
Imikhuba yokungalali kahle ingabangela ukuvuvukala. Ngokunciphisa nje ukulala kwakho kube amahora angu-6 ngesonto, uthola ukuphakama kwama-cytokines avuthayo. Ngakho-ke uma kunenkinga yenhlanzeko yokulala (igama eliwubukhazikhazi elisho ukuthi uziphatha kanjani ngaphambi kokulala) noma ukuntula izakhi ezithonya ikhono lakho lokulala, udinga ukukulungisa lokho. Ngoba uma ungakacindezeleki kakade, imikhuba yakho yokulala engalungile izokwandisa ukuvuvukala futhi idale izimpawu zokucindezeleka.
Kodwa uma usuvele unokucindezeleka, akumangazi ukuqaphela ukuthi ukuphazamiseka kokulala kungaba umphumela wokukhiqizwa kwakho kwe-neurotransmitter engcolile ye-serotonin. Lokhu kungenxa yokuthi udinga amazinga anele e-serotonin ukwenza i-melatonin. Futhi uma ungayikhiqizi i-melatonin eyanele, ngokuzumayo uba isikhova sasebusuku, futhi simosha bonke ubuthongo bakho!
Ukuhlola Ukuvuvukala
Ngakho udokotela wakho ukubheka kanjani ukuvuvukala? Indlela elula ukuhlola igazi. Kuzodingeka ucele udokotela wakho lokhu kuhlolwa. Futhi uma udokotela wakho enquma ukuba nzima ngakho, vele uzitholele ngokwakho.
Ngizophinde ngenze amaklayenti athole i-CRP noma i-hs-CRP yawo nge-Ulta Lab Tests. Akubizi, futhi ungadonsa igazi elebhu eseduze nasekhaya. Uma ubhalisa nabo, ngokuvamile bazokunikeza amakhodi esaphulelo nge-imeyili.
Uzofuna ukuthola i-C-reactive protein (CRP) noma i-C-reactive protein (hs-CRP) ezwela kakhulu. Kuyindlela yokuhlola izifo nezifo ezivuvukalayo. Kuwuphawu oluwusizo kakhulu lokuvuvukala. Ukuhlola igazi okulula okubonisa ukuvuvukala okungapheli. Uma iphakeme, ungabheka ujule ngembangela futhi usebenze nodokotela ukuze uthole isithombe esingcono sezici ze-neuroinflammatory ezikhona.
Okunye ukuhlolwa kwegazi ongase ufune ukukuthola uma unokucindezeleka kuhlanganisa iphaneli ye-cholesterol (i-cholesterol ephansi ihlotshaniswa nokwanda kokuzibulala), i-B6, B12, i-ferritin, ne-vitamin D. Lokhu akuhlobene nokuvuvukala ebuchosheni futhi cishe kuyoba okuxoxwe ngakho kokuthunyelwe kwebhulogi okuzayo. Kodwa uma uzama ukuthola ukuthi yini ongase uyidinge ukuze welaphe ukudangala, ingaba omaka abawusizo kakhulu.
Olunye uphawu oluwusizo kakhulu lokuvuvukala lungabonakala kusetshenziswa i-Organic Acids Test. Lokhu ukuhlolwa kokusebenza. Uma uya kudokotela wakho ojwayelekile, maningi amathuba okuthi bangazi ukuthi ukhuluma ngani. Lokho akusho ukuthi awukwazi ukufinyelela kuyo noma awukwazi ukumela impilo yakho futhi uthole udokotela ongakusiza.
Umaka ekuhlolweni kwe-Organic Acids okuwusizo ukubonwa yi-quinolinic acid. Kuwuphawu oluqondene ngqo nokuvuvukala kobuchopho. I-Quinolinic acid yilokho okwenzeka lapho leyo enzyme (IDO) esisanda kukhuluma ngayo yehlisa i-tryptophan. Kuhileleke ekucindezelekeni kanye nazo zonke izinhlobo zezinye izifo ze-neuropsychiatric (isb, i-OCD, ukukhathazeka, njll.). Kuyi-neurotoxic. Uma unamazinga aphezulu e-quinolinic acid, sidinga ukukuhlanza lokho!
I-quinolinic acid ephezulu ngenxa yama-cytokines avuthayo yandisa i-glutamate ebuchosheni futhi ilinganisele ama-neurotransmitters akho. Uthola inani le-glutamate eliyi-neurotoxic. Njengokungathi lezo bekungezona izindaba ezimbi ngokwanele, futhi ukhiqiza i-GABA encane. Futhi ngithembe, ufuna i-GABA eyengeziwe. I-GABA iyindlela yokuzizwa kahle, "konke kuhamba kahle ngomhlaba," futhi "unalokhu" i-neurotransmitter. Ufanelwe i-GABA eyengeziwe.
Ngakho-ke usunakho. I-Neuroinflammation cishe ibangela izimpawu zakho zokucindezeleka. Manje ake sixoxe ngokuthi yini ongayenza ngakho. Qiniseka ukuthi ubheka ezinye izihloko ezimbili kulolu chungechunge!
Uma ufuna ukufunda kabanzi mayelana nezinqubo eziyisisekelo ezibangela ukudangala ngokuningiliziwe, uzokujabulela okuthunyelwe kwami ngesihloko.
Izinsiza ezinhle ezimayelana nezithasiselo zokudangala zingatholakala ku I-Psychiatry Ichazwe Kabusha. Bahlinzeka ngama-webinars amahhala futhi ungase ukwazi ukusiza ekutholeni umhlinzeki wezifo zengqondo osebenzayo eduze nawe.
Enye insiza enkulu yokudla ukuze ulwe nokucindezeleka yi-Georgia Ede, indawo ye-MDs ukuxilongwadiet.com
Ngifuna futhi ukuthi uqaphele, ukuthi ubuthi be-heavy metal bungabangela isimo se-neuroinfigueation esingase siqhubeke futhi kube nzima ukuselapha ngaphandle kwezindlela zokwelapha ezengeziwe. Uma ungabonakali ukuqeda isimo sakho sengqondo noma izinkinga zezinzwa, ngikukhuthaza ukuthi ufunde okuthunyelwe kwebhulogi ngezansi ukuze ufunde ukuthi ungaqhubeka kanjani nokufuna usizo olwengeziwe.
Ungase ube yikhandidethi elihle lohlelo lwami lwe-inthanethi olubizwa ngokuthi Uhlelo Lokubuyisela Inkungu Yobuchopho. Ungafunda kabanzi ngakho ngezansi:
Ngoba unelungelo lokwazi zonke izindlela ongazizwa ungcono ngazo.
8 Amazwana