Kwenzakalani ngalokhu kuqubuka kwe-keto?
Isikhathi sokufunda esilinganiselwe: 15 imizuzu
Lesi sihloko sizokhuluma ngento ebizwa ngokuthi i-keto rash, okungenzeka kwabanye abantu abaqala ukudla kwe-ketogenic. Sizobuyekeza izindatshana ezithile ezabiwe nami ngu UMarco Medeot. Uma uku-LinkedIn futhi ungalandeli uMarco, ake ngikuqinisekise ukuthi uyaphuthelwa. Ngempela wabelana ngezihloko ezinhle kakhulu mayelana nokudla kwe-ketogenic, futhi unolwazi oluningi ngesihloko. Uhlanganyela ucwaningo oluhle kakhulu, angikwazi ngobuqotho ukuqhubeka! Kodwa uma ngimtshela ukuthi kuma-comments akhe e-LinkedIn, ungitshela ukuthi ngiqhubeke! Ngakho sesilapha.
Isingeniso
Okokuqala, ake sikhulume ngokuthi kuyini lokhu kuqubuka. Empeleni inegama futhi ibizwa ngokuthi i-Prurigo Pigmentosa (PP).
Esihlokweni esithi "Prurigo Pigmentosa - I-Multi-Institutional Retrospective Study," eyanyatheliswa kuyi-Journal of the American Academy of Dermatology, abacwaningi benza ukuhlaziywa okuphindaphindiwe kweziguli ze-30 ezitholwe ukuthi zine-Prurigo Pigmentosa. Ucwaningo lwembula ukuthi i-40% yalezi ziguli yayidla ukudla kwe-ketogenic ngaphambi kokuqala kwezimpawu, okwakuhlanganisa ngokuyinhloko i-pruritus kanye ne-hyperpigmentation, ethinta kakhulu ingemuva nesifuba. Ukuhlolwa kwe-histopathological ngokuvamile kwabonisa ukuthi i-spongiosis encane kanye ne-lymphoplasmacytic infiltrate, nama-neutrophils nama-eosinophils kube ukutholakala okungajwayelekile.
Ake sichaze amanye alawo magama.
- i-spongiosis ethambile - Ukuvuvukala noma ukunqwabelana koketshezi phakathi kwamaseli esikhumba oqweqweni olungaphandle lwesikhumba
- i-lymphoplasmacytic infiltrate - Amaseli omzimba ahlangene endaweni ethile yezicubu. Lokhu kuvame ukusabela kolunye uhlobo lokuvuvukala, ukutheleleka, noma okunye ukuvuselela amasosha omzimba.
- ama-neutrophils - Ngokuvamile amangqamuzana omzimba okuqala ukufika endaweni yokutheleleka noma ukulimala. Basabela ngokushesha ezimpawini zokuhlasela amagciwane, amagciwane, noma amanye amagciwane. Omunye wemisebenzi yazo eyinhloko i-phagocytosis, lapho egwinya futhi egaya amagciwane ahlaselayo.
- ama-eosinophils - Ingxenye yamasosha omzimba futhi ibandakanyeka ezindleleni zokuzivikela zomzimba. Mancane kunezinye izinhlobo zamangqamuzana amhlophe egazi, njengama-neutrophils, kodwa abalulekile ekulweni nezifo ezibangelwa amagciwane kanye nasekuphenduleni kokungezwani komzimba.
Lesi sihloko siqhubeka sithi ukwelashwa okuphumelelayo kwe-PP kwatholakala ukuthi ama-antibiotic omlomo, okwaholela ekuxazululeni okuphelele kuzo zonke iziguli ezilashwa, kuyilapho i-corticosteroids yama-topical inikeze ukukhululeka kwesikhashana kuphela. Igcizelele izingcupho ezehlukene nezethulo ze-PP, igqamisa ukusabalala kwayo kuyo yonke iminyaka ehlukene nobulili, nokugqama kwabesifazane. Futhi kubonisa ukuthi akuwona wonke amacala ahlotshaniswa nokudla kwe-ketogenic.
Kodwa akuthakazelisi yini ukuthi kunomsebenzi omningi obukhali kumaseli omzimba? Qaphela lokho, ngoba ngizokwabelana nge-hypothesis ezungeze lokho njengengxenye yalesi sihloko. Qhubeka ufunda!
Isifundo Se-Case 1
Esihlokweni esithi "I-Prurigo Pigmentosa Ngemva Kokudla Kwe-Keto Nokuhlinzwa Kwe-Bariatric," isifundo sivezwa ngowesifazane oneminyaka engu-25 ubudala owahlakulela isimo sesikhumba esaziwa ngokuthi i-Prurigo Pigmentosa (PP) ngemva kokuhlinzwa komkhono wesisu nokulandela ukudla okune-ketogenic. . Lesi simo, esibonakala ngokuqubuka okuqale njengama-papules amancane abomvu futhi kwaqhubekela phambili kuma-plaque amakhulu, akuyona into engavamile phakathi kwabantu abadla ukudla kwe-ketogenic. Ngokuthakazelisayo, isiguli sasike sabhekana nokuqhuma okufanayo ngesikhathi somzamo wangaphambili wokudla kwe-ketogenic. Kuzo zombili izimo, ukuqubuka kwaba ngcono kakhulu lapho ebuyisela ama-carbohydrate ekudleni kwakhe. Ngemva kokuhlinzwa, ukuqubuka kwaqala kwaba ngcono ngokusetshenziswa kwe-oral minocycline, uhlobo lwemithi elwa namagciwane, kanye nokwanda kokudla okunama-carbohydrate, kodwa akuzange kunyamalale ngokuphelele kwaze kwaba yilapho ehlala egcina ukudla okunama-carbohydrate amaningi. Leli cala liqokomisa isixhumanisi esingaba khona phakathi kwezinguquko zokudla, ikakhulukazi lezo eziholela ku-ketosis, nokuthuthukiswa kwe-PP, kuyilapho futhi kugcizelela ukuphumelela kokulungiswa kokudla ekuxazululeni lesi simo. Ukuqubuka ngokuvamile kuqedwe esikhathini esiyinyanga lapho ukudla okuvamile, okunothe nge-carbohydrate kuqaliswe kabusha.
Lesi sethulo singase siphakamise a
Alkhouri, F., Alkhouri, S., & Potts, GA (2022). I-Prurigo Pigmentosa Elandela Ukudla Kwe-Keto Nokuhlinzwa Kwe-Bariatric. Cureus, 14(4), e24307. https://doi.org/10.7759/cureus.24307
ubudlelwano obuqinile phakathi kwe-PP kanye nesimo se-metabolic somzimba.
Isifundo Se-Case 2
isihloko esithi "Ukukhululwa Kwe-Prurigo Pigmentosa Ngemva Kokuphula Ukudla Kwe-Ketogenic Nokuphinde Uqale Ukudla Okuvamile," kusobala ukuthi isiguli, owesifazane oneminyaka engu-21 ubudala, welulekwa ngempela ukuba ayeke ukudla kwe-ketogenic futhi athathe i-minocycline ku-Prurigo Pigmentosa (PP) yakhe. . Nokho, wakhetha ukuqhubeka nokudla okuvamile ngaphandle kokuthatha imithi. Ngemva kwalolu shintsho ekudleni kwakhe, izilonda esikhumbeni sakhe zaphela phakathi nezinyanga ezimbili, kwasala kuphela umbala onsundu okhanyayo wangemuva kokuvuvukala. Kwakungekho ukuphindaphinda kwe-PP ngemva kwezinyanga ezingu-12 zokulandelela kusukela ephinde waqala ukudla okune-carbohydrate ephakeme. Leli cala liqokomisa amandla okuguqulwa kokudla kuphela ukuze kuphumelele ekuxazululeni i-PP, ikakhulukazi uma kuhlotshaniswa nokudla kwe-ketogenic.
Owesifazane oneminyaka engu-21 ophile saka
Daneshpazhooh, M., Nikyar, Z., Kamyab Hesari, K., Rostami, E., Taraz Jamshidi, S., & Mohaghegh, F. (2022). Ukuxolelwa kwe-prurigo pigmentosa ngemuva kokuphula ukudla kwe-ketogenic nokuqala kabusha ukudla okuvamile. Ucwaningo Lwezempilo Oluthuthukile, 11, 70. https://doi.org/10.4103/abr.abr_138_21
evezwe nezilonda zesikhumba ezilumayo ngaphezulu
isifuba nentamo ishintsha amaviki ama-2.
Ukuqubuka kwenzeke iviki elingu-1 ngemuva kokuqala a
I-KD ekhawulelwe nge-carbohydrate.
Isifundo Se-Case 3
Embikweni wecala onesihloko esithi 'Prurigo Pigmentosa Post-Bariatric Surgery,' isiguli sesilisa saseSaudi esineminyaka engu-25 sabhekana nesenzakalo esiyingqayizivele se-Prurigo Pigmentosa ngemva kokuhlinzwa kwe-bariatric, ukuhlukana nesimo sabantu esivamile. Ngokuphawulekayo, ngemva kwezinsuku ezingu-18 ehlinziwe, waba nokuqubuka kwesikhumba, isisu esingenhla, nesifuba. Okutholwe nge-pathological kusuka ku-biopsies yesikhumba kwembula ukusabela kwe-focal interface, i-necrotic keratinocyte ehlakazekile, izinhlayiya zezinwele ezinwetshiwe ezigcwele amagciwane, kanye ne-acanthotic dermis ethambile enama-lymphocyte e-perivascular, ama-eosinophils, namangqamuzana egazi abomvu e-extravasated. Lokhu okutholakele kusikisela ukusabela okuthuthukisiwe kokuzivikela komzimba, amasosha omzimba okungenzeka aqondise ezindabeni ebezingaxazululiwe ngaphambilini esikhumbeni. Ukuqubuka kwesiguli kuxazululwe ngokuphelele emasontweni amabili okwelashwa ngemithi ye-topical neyomlomo, nakuba i-hyperpigmentation yangemuva kokuvuvukala iphikelela. Leli cala ligqamisa amandla okuthi i-PP ibonakale emiphakathini nasezimeni ezihlukahlukene, futhi igcizelela indima yamasosha omzimba acushiwe ekuphenduleni izinguquko esimweni sokusebenza komzimba.
Namuhla, amacala e-Prurigo pigmentosa (PP) abikwa emhlabeni wonke, kuhlanganise namacala e-PP avele ngemva kokuhlinzwa kwe-bariatric yokulahlekelwa isisindo ngaphandle kokuguqulwa kokudla kwe-ketogenic.
Jazzar, Y., Shadid, AM, Beidas, T., Aldosari, BM, & Alhumidi, A. (2023). I-Prurigo pigmentosa post-bariatric surgery: umbiko wecala. Imibiko yecala le-AME, 7, 43. https://dx.doi.org/10.21037/acr-23-45
Isifundo Se-Case 4
Ocwaningweni oluthi "I-Ketogenic Diet-induced Prurigo Pigmentosa (the 'Keto Rash'): A Case Report and Literature Review," eyanyatheliswa kuyi-Journal of Clinical and Aesthetic Dermatology, indoda eneminyaka engu-21 ubudala yase-Hispanic yabhekana nokusabela okuphawulekayo kwesikhumba ngemuva kocwaningo. ukunamathela ekudleni kwe-ketogenic. Wakha i-Prurigo Pigmentosa (PP), ebonakala ngokuqubuka kwe-pruritic esifubeni nasemhlane ongenhla, okwaqhubeka amasonto amathathu. Ukuqhuma kwavela ngemva kwezinyanga ezimbili ekudleni, lapho ehle khona ngamakhilogremu angu-20. Ukuhlolwa komtholampilo kwembule ama-papules ane-erythematous to hyperpigmented papules ehlangana abe ama-plaque azacile. I-biopsy yesikhumba iqinisekise ukuhlonzwa kwe-PP, okubonisa i-spongiosis kanye nokungena kwe-perivascular okungaphezulu kwama-eosinophils, ama-lymphocyte, nama-neutrophils angavamile. Ukwelashwa kwesiguli kwakuhilela i-doxycycline yomlomo kanye nokuyeka ukudla kwe-ketogenic, okuholela ekuxazululeni kwe-pruritus phakathi namasonto amabili nokuguqulwa kancane kancane kwama-erythematous plaques abe ama-patches asymptomatic, hyperpigmented. Leli cala liqokomisa izinkinga zesikhumba ezingase zibe khona ezihlobene nezinguquko zokudla, ikakhulukazi ukudla kwe-ketogenic kanye nendima yayo ekuqaliseni i-PP.
odokotela besikhumba kufanele babuyekeze imikhuba yokudla yazo zonke iziguli ezethula nazo
Xiao, A., Kopelman, H., Shitabata, P., & Nami, N. (2021). I-Ketogenic Diet-induced Prurigo Pigmentosa (i-“Keto Rash”): Umbiko Wendaba kanye Nokubuyekezwa Kwezincwadi. Ijenali yeClinical and Aesthetic Dermatology, 14(12 Suppl 1), S29–S32. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8903224/
i-pruritic erythematous papular ephumayo
ukuqubuka esiqwini, bese ucabangela i-Prurigo Pigmentosa (PP) phezulu
yokuhluka kwabo kunoma yisiphi isiguli esiveza ukuqhuma kwesikhumba ngemva kokuqala ukudla kwe-ketogenic.
Isifundo Se-Case 5
Ocwaningweni olunesihloko esithi 'Icala Elingavamile Le-Prurigo Pigmentosa ku-Danish Sibling Couple,' izingane zakubo ezimbili zase-Danish ezinempilo, ezineminyaka engu-16 no-18, zakha i-PP cishe amasonto amabili ngemva kokuqala ukudla okune-ketogenic. Ukuhlolwa kwe-histopathological yesikhumba sabo kwembula izici ezihlukile. I-biopsy yengane eneminyaka engu-18 ubudala yabonisa izinguquko ze-incrustation, i-spongiosis, kanye ne-focal lichenoid ene-eosinophilic ikakhulukazi kanye nama-neutrophilic granulocyte ku-dermis. I-biopsy yengane eneminyaka engu-16 ubudala yabonisa i-hyperkeratosis ethambile, i-epidermal hyperplasia ethambile enama-necrotic keratinocyte ambalwa, kanye nokungena okuncane kwesikhumba se-lymphocyte nama-melanophages. Lokhu okutholakele kuqokomisa izinguquko eziyinkimbinkimbi ze-dermatological ezihlobene ne-PP, ikakhulukazi kumongo wokudla kwe-ketogenic.
Ake ngicacise ngolimi olulula ukuthi i-biopsy yatholani. Bathola isikhumba esiqinile, esinamaqhuqhuva, futhi kwesinye isikhathi esilumayo esasibambelele oketshezini oluningi kunalokho obekufanele ngenxa yokuvuvukala. Futhi lapho bebheka ukuthi hlobo luni lwamaseli noshintsho oludala lokhu, bathola, njengakwezinye izifundo, ama-neutrophils nama-eosinophils. Ukuphakamisa ukuthi umzimba wawusabela kokuthile okuhlobene nokuqubuka.
Iziguli eziningi ezine-PP azinayo i-ketosis noma isifo sikashukela, futhi izimo zethu ziphakamisa umbuzo wokuthi ingabe izinhlobo ezithile zezicubu (isb, izinhlobo ze-HLA) zinomkhawulo ohlukile emizimbeni ye-ketone egazini futhi ngaleyo ndlela maningi amathuba okuba kwakheka i-PP.
Danielsen, M., Pallesen, K., Riber-Hansen, R., & Bregnhøj, A. (2023). Icala elingavamile le-Prurigo Pigmentosa ku-Danish Sibling Couple. Imibiko Yecala ku-Dermatology, 15, 26–30. https://doi.org/10.1159/000528422
Pho, kwenzekani lapha? Angazi. Angiyena uchwepheshe wamasosha omzimba. Kodwa ngine-hypothesis evamile ezokwenza ngethemba ukuthi le mpendulo evamile abanye abantu abanayo ekudleni kwe-ketogenic.
Ukusebenzisana Okuyinkimbinkimbi Phakathi Kokudla Kwe-Ketogenic kanye Nokuguqulwa Kwesistimu Yamasosha omzimba
Ngakho-ke wonke umuntu uyazi, ngalesi sikhathi, ukuthi ukudla okune-ketogenic kuyindlela yokudla enamafutha amaningi, amaprotheni aphakathi nendawo, kanye ne-carbohydrate ephansi eqala futhi egcina ushintsho olujulile lwe-metabolic emzimbeni womuntu, okuholela esimweni se-ketosis.
Uma ulandela le bhulogi nhlobo, uyazi ukuthi lesi simo, esibonakala ngokukhiqizwa okuphezulu kwemizimba ye-ketone efana ne-β-hydroxybutyrate (BHB), i-acetoacetate, ne-acetone, akuyona nje enye indlela ye-metabolic ekukhiqizeni amandla asekelwe ku-glucose; imele ukuhlelwa kabusha okubalulekile kwemisebenzi yeselula neyesistimu. Kunezihloko eziningi kule bhulogi ezixoxa ngemiphumela ekuphenduleni kokuzivikela komzimba kobuchopho nokuthi lokho kulungisa kanjani i-neuroinflammation.
Kodwa ngenxa yokuthi le bhulogi igxile kakhulu ku-noggin yakho, asikakangeni emiphumeleni efinyelela kude yokudla kwe-ketogenic kumasosha omzimba ngokujwayelekile.
Ezingeni lamaselula, imizimba ye-ketone, ikakhulukazi i-BHB, inethonya elilawulayo emizileni ebalulekile yokuzivikela komzimba. I-BHB yaziwa ngokuvimbela i-NLRP3 inflammasome, inkimbinkimbi ye-multiprotein ngaphakathi kwe-neutrophils edlala indima ebalulekile ekuphenduleni kwamasosha omzimba nokuvuvukala. Ukusebenza kwe-NLRP3 inflammasome kuholela ekukhishweni kwama-cytokines abangela ukuvuvukala, njenge-IL-1β ne-IL-18, abalulekile ekulweni nezifo kodwa futhi angaba nomthelela ekuvuvukeni kwe-pathological. Ngokuguqula umsebenzi we-NLRP3 inflammasome, i-BHB ingakwazi ukunciphisa izimpendulo zokuvuvukala ngokweqile, iphakamisa umphumela wokulinganisa kumasosha omzimba.
Ngaphezu kwalokho, umthelela wokudla kwe-ketogenic udlulela ku-gut microbiome, ingxenye ebalulekile yamasosha omzimba. I-gut microbiota iyi-ecosystem eyinkimbinkimbi ethonya ukungatheleleki kwesistimu. Izinguquko zokudla zithinta kakhulu ukwakheka nokusebenza kwale microbiome, ngaleyo ndlela kuguqule isimo sokuzivikela komzimba. Ukudla kwe-ketogenic kungaholela ku-gut microbiota ethanda izimo zokulwa nokuvuvukala, okungenzeka kuthuthukise ikhono lomzimba lokuphatha izimo ze-autoimmune kanye nezimpendulo zokuvuvukala.
I-β-HB ilawula ukusebenza kwe-NLRP3 inflammasome kuma-neutrophils nama-macrophages. I-trajectory ye-caspase-1 ibalulekile ekuqhekekeni kwama-precursors amaprotheni amaningana kanye nesici esibalulekile esimisweni somzimba sokuzivikela. Ukuvimbela i-K+ efflux okuvela ku-β-HB kuvimbela ukusebenza kwe-NLRP3 inflammasome. Imizimba ye-Ketone yenza kusebenze ama-HCA2 receptors futhi ivimbele ukuhlangana kwe-NLRP3 inflammasome.
Ansari, MS, Bhat, AR, Wani, NA, & Rizwan, A. (2022). Izindlela Ze-Antiepileptic Zokudla Kwe-Ketogenic. I-Neuropharmacology yamanje, 20(11), 2047-2060. I-DOI: 10.2174/1570159X20666220103154803
Kodwa kwenzekani kulokhu kuqubuka kwe-keto? Ingabe ukudla kwe-ketogenic akufanele kunciphise izimpendulo zokuvuvukala? Yebo yebo! Kodwa…
Esimweni sempilo yesikhumba nezimo ezifana ne-Prurigo Pigmentosa (PP), imiphumela ye-ketogenic ye-immunomodulatory ibaluleke kakhulu. Isikhumba, isitho sokuzivikela esisebenzayo, siyikhaya lamangqamuzana omzimba ahlukahlukene, kuhlanganise nama-neutrophils nama-eosinophils. Lawa maseli abalulekile ekuphenduleni kwamasosha omzimba, asebenza njengabaphenduli bokuqala ekuthelelekeni nasekuvuvukeni. Ku-PP, ukungena kwama-neutrophils nama-eosinophil ezilonda zesikhumba kubonisa ukusabela okusebenzayo kokuzivikela komzimba. Ukudla kwe-ketogenic, ngemiphumela yayo yesistimu neyendawo, kungase kube nomthelela kule mpendulo. Ngokushintsha i-immune cell metabolism kanye nokuguqula izindlela zokuvuvukala, ukudla kungaba nomthelela ekuthuthukisweni noma ekulinganiseni kabusha ubukhona bomzimba esikhumbeni.
Ngiwuthathaphi lo mcabango othobekile? Kungani izincwadi zesayensi, kunjalo. Le nkolelo-mbono ibuye isekelwe ucwaningo ekudleni kwe-ketogenic kwezinye izimo, njengokwelashwa komdlavuza. Ucwaningo lomdlavuza lwembule ukuthi ukudla kwe-ketogenic kungathinta ukukhula kwesimila kanye nokubhekwa komzimba. Nakuba izindlela ziyinkimbinkimbi futhi zinezici eziningi, isici esisodwa ukuguquguquka kwezimpendulo zamasosha omzimba, okuthuthukisa ikhono lomzimba lokukhomba nokubhubhisa amangqamuzana omdlavuza. Lokhu kuphakamisa ukuthi ukudla kwe-ketogenic kunamandla okuba nomthelela omkhulu ekusebenzeni kokuzivikela komzimba, hhayi nje kumdlavuza kodwa kwezinye izimo lapho izimpendulo zokuzivikela komzimba zibalulekile.
Yiziphi ezinye izici ezingase ziqhubeke? Hhayi-ke, angazi! Kodwa ngokusekelwe kulokho engikuqondayo mayelana nokudla kwe-ketogenic nokuphendula komzimba? Ngicabanga ezinye zalezi!
I-hypothesis: Ukudla kwe-Ketogenic kanye Nokuguqulwa Kwesistimu Yamasosha omzimba
I-Metabolic Shift kanye Nokusebenza Kweseli Lomzimba Amasosha omzimba
Ake sidlule kwezinye zezendlalelo ezithintekayo ekwandeni kokusabela komzimba esikubona nge-Keto Rash.
Izinguquko ze-metabolic zibalulekile ekusebenzeni kwamasosha omzimba
Ukudla kwe-ketogenic kudala ushintsho lwe-metabolic kusuka ku-glucose kuya emizimbeni ye-ketone ukuze ibe namandla. Lokhu kushintshwa kungathonya amaseli omzimba, njengoba imithombo yamandla ehlukene ingashintsha umsebenzi wawo. Isibonelo, imizimba ye-ketone ingase iguqule ukusebenza nokusebenza kwamangqamuzana omzimba omzimba njengama-neutrophils nama-eosinophils, avame ukubonakala ezilonda ze-PP. Imizimba ye-Ketone iboniswe ukuthi ivimbela i-NLRP3 inflammasome, ingxenye yesimiso somzimba sokuzivikela esithintekayo ekuvuvukeni. Lokhu kungase kunciphise ukuvuvukala okungamahlalakhona kodwa kungase futhi kuthuthukise ukusabela komzimba ezinkingeni ezinkulu, njengamagciwane noma amaseli alimele.
I-β-HB ilawula ukusebenza kwe-NLRP3 inflammasome kuma-neutrophils nama-macrophages
Kumar, A., Kumari, S., & Singh, D. (2022). Ukuqonda Ngokusebenzisana Kweselula kanye Nezinqubo Zemolekyuli Zokudla Kwe-Ketogenic Zokulawulwa Okuphelele Kwesithuthwane. Amaphrinta, 2022120395. https://doi.org/10.20944/preprints202212.0395.v1
I-Gut Microbiome kanye Nempendulo Yamasosha omzimba
Ukudla kwe-ketogenic kushintsha kakhulu i-gut microbiome. Njengoba ingxenye enkulu yamasosha omzimba itholakala emathunjini, izinguquko ekubunjweni kwe-microbiome zingaba nemiphumela ejulile ekuphenduleni komzimba.
I-gut microbiome enempilo, evame ukuhlotshaniswa nokudla kwe-ketogenic, ingase ithuthukise ikhono lomzimba lokulwa nezifo futhi ingachaza ukusabela okulawulwayo kokuzivikela komzimba esikhumbeni.
Ukunciphisa Ukuvuvukala
Izidlo ze-Ketogenic ziyaziwa ukunciphisa ukuvuvukala kwesistimu. Lokhu kwehliswa kungavumela ngokuxakayo ukuthi amasosha omzimba agxile ngempumelelo ezindabeni zasendaweni, njengezimo zesikhumba ku-PP. Ukuncipha kwezimpawu zokuvuvukala kwesistimu kungase "kuvule" izimo ezingaphansi komtholampilo, okuholela ekwandeni okusobala komsebenzi wokuzivikela komzimba ezindaweni ezithile njengesikhumba.
I-Oxidative Stress kanye Nokuqapha Amasosha omzimba
Kuyaziwa kahle ezincwadini zesayensi, ukuthi ukudla kwe-ketogenic kungathonya amazinga okucindezeleka okwenziwe nge-oxidative emzimbeni. Ukulinganisela ekucindezelekeni kwe-oxidative kubalulekile ekusebenzeni kahle kokuzivikela komzimba. Ukuncipha kwengcindezi ye-oxidative kungase kuthuthukise ukubhekwa kwamasosha omzimba, kuvumele amasosha omzimba ukuthi akhombe ngokuphumelelayo futhi aphendule amagciwane noma amaseli angajwayelekile, angabonakala ekuphenduleni kwesikhumba kwe-PP.
Izinguquko zeHormonal neCytokine
Ukudla kwe-Ketogenic kungashintsha amazinga e-hormone nokukhiqizwa kwe-cytokine. Lezi zinguquko zingaba nemiphumela ehlukahlukene ohlelweni lokuzivikela komzimba, okungenzeka luthuthukise ukuphendula kwalo noma luguqule imigomo yalo. Isibonelo, izinguquko emazingeni e-insulin kanye nezici zokukhula ezifana ne-insulin zingathonya ukuvuvukala nokusebenza kwamangqamuzana omzimba omzimba.
Ngakho-ke, ngokuzithoba ngibeka umbono wokuthi umthelela wokudla kwe-ketogenic kumetabolism, i-gut microbiome, ukuvuvukala, ukucindezelwa kwe-oxidative, nokulinganisela kwamahomoni kungahlanganisa ngokuhlanganyela amasosha omzimba. Lokhu kuguquguquka kungase kubonakale njengendlela yokusabela okuthuthukisiwe noma okuhloswe kakhudlwana kokuzivikela komzimba ezimweni ezithile ezifana ne-PP, lapho sibona ukwanda kwamangqamuzana omzimba njengama-neutrophils nama-eosinophils esikhumbeni.
Isiphetho
Akukho kulokhu okuzwakala kuthusa kimi. Kuzwakala njengokulungiswa kokungalungile. Hhayi isiphazamisi, kodwa ukubuyisela ibhalansi yomzimba. Akuyona i-alamu, kodwa ukulungiswa kabusha kwempilo yomzimba. Futhi ngokuqinisekile akusona isimo esiphuthumayo se-pathological esidinga ama-antibiotics noma ukuyekwa okubulalayo kokudla okuhlinzeka ngokwelashwa kwe-metabolic esigulini.
Ekuphetheni, ukudla kwe-ketogenic kumelela ukungenelela okuphawulekayo kumetabolism yomuntu enemiphumela ejulile kumasosha omzimba. Amandla ayo okushintsha izindlela eziyinhloko zokuzivikela komzimba, ukuguqula i-gut microbiome, futhi ibe nomthelela ekuphenduleni kwesistimu nokuzivikela kwendawo iphakamisa indlela engase ibe khona ngemuva komsebenzi wokuzivikela othuthukisiwe obonwa ezimeni ezifana ne-PP. Lokhu kusabela okuthuthukisiwe noma okulinganiselayo kokuzivikela komzimba kungase kube ukubonakaliswa kokujwayela komzimba esimweni esisha sokugayeka kokudla, okunomthelela ezimeni ezihlukahlukene zempilo, okuhlanganisa ukuphazamiseka kwesikhumba, izifo ezizimele, kanye nomdlavuza imbala.
Emsebenzini wami neziguli, angizange ngibe nomuntu okuqubuka okungahambanga kuye ngesineke futhi, ngokunokwenzeka, ukuguquka okuhamba kancane kakhulu ekusetshenzisweni kwama-carbohydrate. Ngokwesikhundla sami njengomqeqeshi wezempilo, angikaze ngiphakamise ukuthi noma ngubani afune ama-antibiotic. Ngenxa yolwazi lwami lomtholampilo, sengiyazi kakade ukuthi ama-antihistamine namakhilimu e-cortisol noma amajeli ngeke alenze iqhinga. Ngitshela iziguli zami ukuthi lokhu kuqubuka kungase kube uphawu oluhle lokuthi amasosha omzimba azo aphinde alinganisele noma alawuleke. Ngiyazi ukuthi ngangiyiqedile futhi ngiqhubeke izinyanga ezimbalwa lapho ngishintshela ekudleni kwami kwe-ketogenic. Ngezinye izikhathi kwakulunywa kakhulu futhi kungakhululekile, kodwa ekugcineni kwahamba. Futhi ngiyathuthumela uma ngicabanga ukuthi ngabe ngabe ngiyekile futhi ngiyeka ukudla kwami kwe-ketogenic njengempendulo kukho, ngoba ngiyakuqinisekisa, ubuchopho bami ngeke busebenze kahle njengoba bunjalo namuhla ukuze ngikubhalele lesi sihloko.
Angikho emzimbeni wakho olumayo, we-keto-rash. Ngakho-ke, lokho okwenzayo nendlela okhetha ukuphendula ngayo ngokuqinisekile kukuwe. Akukho ukwahlulela okukhona ngakimi, ngiyakuqinisekisa. Ngifuna uzizwe ukahle.
Kodwa ngifuna wazi ukuthi kungaba khona incazelo yokuthi kwenzekani okungeyona "impendulo ye-pathological" njengoba udokotela wesikhumba ojwayelekile noma i-MD eqeqeshelwe i-non-ketogenic noma udokotela wezokwelapha osebenzayo angase asho noma acabange. Uma kukukhathaza ngempela, khuphuka kuma-carbs akho mayelana namagremu angu-5 noma angu-10 futhi usebenze nodokotela wakho wezokudla noma uchwepheshe wezokudla. Bheka ukuthi lokho kuyawenza yini ubuqili. Kepha kusengenzeka ngokwezinga elithile lapho wehla i-carb ephansi ngokwanele ukuthi umlingo we-metabolic uqale ukwenzeka.
Nakhu imithi yesimanje engakutsheli yona. Ngenxa yokuthi igxile kakhulu ekulawulweni kwezimpawu esikhundleni sokuphulukisa imbangela, angicabangi ukuthi iyazi. Kodwa ukuphulukiswa kuyinkimbinkimbi. Ayikhululekile. Kodwa kuwukuhlakanipha. Umzimba wakho cishe ulungisa izinto futhi wenza izinguquko ngezindlela wena kanye/noma uchwepheshe wakho wezokwelapha, noma mina ngokwami njengomuntu onentshisekelo enkulu kulesi sihloko, engeke nakancane ngiqale ukuziqonda.
Ngikukhuthaza ukuthi unwebe lokho ozimisele ukukuhlola nokubekezelela emgomweni wakho wokuphulukisa. Qhubeka uma ukwazi. Futhi ubone ukuthi yini engenzeka kuwe.
Okubhekwayo
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