Ukudla kwe-Ketogenic kanye ne-Vitamin D Metabolism: Yini Esiyaziyo

Isikhathi sokufunda esilinganiselwe: 6 imizuzu

Ukubuyekezwa kwaphuma kwenza konke okusemandleni ukuphenya imiphumela ye-Ketogenic Diets ku-vitamin D. Ukuba ngumlandeli omkhulu wabo bobabili; Ngicabange ukuthi kuzokwenza okuthunyelwe kwebhulogi okuthakazelisayo futhi kube nomthelela emgomweni wami wokuthi wazi zonke izindlela ongazizwa ungcono ngazo.

Isingeniso

Kulesi sibuyekezo sesayensi, esishicilelwe ngo-Dec 2022, abanye ochwepheshe bamba bajula ocwaningweni lokungenelela nezinye izici ezingase zibe nokuxhumana phakathi kwe-Ketogenic Diets kanye ne-vitamin D. Baze babheka ukusebenzisana kwezakhi zofuzo! Ngakho-ke ngizokhipha lokho abakutholile ukuze uqonde kangcono ukuthi ukudla kwe-ketogenic kungasithinta kanjani isimo sakho se-Vitamin D.

Abacwaningi bathola izifundo ezinhlanu ezenziwe kubantu abadala abanempilo, eyodwa ezifundweni ezinesifo sikashukela sohlobo lwe-2, kanye nezifundo eziyisikhombisa ezifundweni ezinesifo sokuwa ezihlola amazinga kavithamini D ngaphambi nangemva kokungenelela. Yini abayithola? Nasi isifinyezo ukuze kube lula kuwe! ⬇️

Ketoni

Okokuqala, sidinga ukwethula amanye amagama asetshenziswe kule ngxenye yokubuyekezwa kwababhali. Ake ngikwethule ku-25(OH)D kanye no-1,25(OH)2D. Kuzokwenza ukufunda le ngxenye kube lula ukuyiqonda.

25(OH)D isifinyezo se-25-hydroxyvitamin D. Ukuhlolwa kwegazi okusetshenziselwa ukukala izinga likavithamini D emzimbeni wakho. Lapho uvithamini D umuncwa umzimba, uguqulwa ube ngu-25-hydroxyvitamin D (25(OH)D), okuwuhlobo oluyinhloko lukavithamini D olujikelezayo egazini. Ukulinganisa izinga lika-25(OH)D egazini kuthathwa njengendlela engcono kakhulu yokuhlola isimo sikavithamini D womuntu.

1,25(OH)2D isifinyezo se-1,25-dihydroxyvitamin D. Iwuhlobo olusebenzayo lukavithamini D olukhiqizwa emzimbeni ngochungechunge lokusabela kwe-metabolic okubandakanya isibindi nezinso. I-1,25(OH)2D i-hormone esiza ukulawula amazinga e-calcium ne-phosphorus emzimbeni, okubalulekile ekugcineni amathambo enempilo.

Ngokungafani ne-25 (OH) D, ebhekwa njengomaka ongcono kakhulu wesimo se-vitamin D, amazinga we-1,25 (OH) 2D ngokuvamile alinganiswa ukuze ahlole izimo ezithile zezokwelapha ezithinta i-calcium ne-bone metabolism, njengokuhluleka kwezinso, i-hyperparathyroidism, kanye ezinye izifo ezingavamile zofuzo.

Abakutholile ukuthi ekuqaleni, amazinga aphansi kavithamini D avame ukubonwa ezigulini ze-Ketogenic Diet, kodwa ukwesekwa kungakhuphula amazinga e-vitamin D. Ukukhiqizwa kwemizimba ye-ketone nge-Ketogenic Diet kudala indawo ene-acidic engakwazi ukuvala isibindi ne-hydroxylase yezinso, ivimbele ukuguqulwa kwe-vitamin D esimweni sayo esisebenzayo. I-hydroxylase iyi-enzyme enezela iqembu le-hydroxyl (-OH) ku-molecule engaphansi, okuyisinyathelo esibalulekile ezinqubweni eziningi zezinto eziphilayo, njengokuguqulwa kwe-Vitamin D.

Ababhali baxoxa nge-acidosis ebangelwa ukukhiqizwa kwemizimba ye-ketone enganciphisa amaprotheni okubopha i-vitamin D, ukunciphisa inani lokujikeleza kwe-vitamin D esebenzayo. Olunye ucwaningo oluhloliwe olukhonjiwe lubonise ukuthi ukulandela i-KD, i-25 (OH) D yanda, kuyilapho I-1,25(OH)2D yehlisiwe, okuphakamisa umphumela we-KD ku-hydroxylase. Kodwa kwaphawulwa ukuthi i-1,25(OH)2D ine-half-life emfushane futhi ingase ingabi inkomba ethembekile yesimo se-vitamin D.

Futhi sicela uqaphele ukuthi ukudla okwenziwe kahle kwe-ketogenic akukhiqizi isimo esingapheli se-acidosis.

AmaMacronutrients

Abantu abadla ukudla okune-ketogenic bavame ukudla ukudla okunamafutha amaningi, okungaholela ekwandiseni ukudla okunovithamini D kanye namazinga aphezulu e-vitamin D ejikelezayo. Olunye ucwaningo lokubheka abaluhlola lwathola ukuthi izifundo ezilandela ukudla okune-carbohydrate ephansi/okunamafutha amaningi. yayinamazinga aphezulu kakhulu angu-25(OH)D uma kuqhathaniswa nalawo adla ukudla okusempumalanga ye-Europe.

Ama-fatty acids ekudleni angaphinde ahlanganyele ne-cholecalciferol ekumunceni emathunjini, futhi ukufakwa kwe-vitamin D kusebenza kakhulu uma kunikezwa ngokudla okunamafutha amaningi. Ama-bile acids, akhuphuka ngemva kokusetshenziswa kwamafutha, kuye kwabikwa ukuthi avule ama-receptors e-vitamin D.

Ukudla okudlayo kwamanye ama-macronutrients, njengamaprotheni, kungase futhi kuthinte ama-enzyme abalulekile we-metabolic kavithamini D. Nokho, ayikho idatha ekhona njengamanje yemiphumela ye-Ketogenic Diets kulawa ma-enzyme abalulekile we-metabolic.

Weight Loss

Kuzo zonke izifundo eziye zahlola imiphumela ye-Ketogenic Diets (KDs) ku-vitamin D ezifundweni ezinempilo, ukulahlekelwa isisindo kwakukhona, okungenzeka ukuthi kufihle imiphumela enetha ye-Ketogenic Diets.

Bathola ucwaningo olulodwa kuphela olwaqhathanisa imiphumela ye-KD ngokumelene nokunye ukudla okwehlisa isisindo (ukudla kwaseMedithera) ekujikelezeni kwe-25(OH)D. Futhi kulolo cwaningo, ngemva kokulahlekelwa isisindo nge-carbohydrate Ketogenic Diet (VLCKD) ephansi kakhulu ye-carbohydrates (VLCKD), ukugxila kwe-serum 25 (OH)D kwanda kakhulu, kuyilapho ngemva kokudla kwaseMedithera, ukwanda kwevithamini D kwakungabalulekile ngezibalo.

IHormonal

Le ngxenye iyathakazelisa futhi ifanele umongo othile ngoba angicabangi ukuthi ixoxwa ngokwanele. Ngakho-ke ngizokwenza okunye ukuchaza ngendlela yesinyathelo ngesinyathelo. Ngeke ufune ukuphuthelwa ukuqonda le ngxenye epholile!

Ukudla kwe-ketogenic (KD) kwaziwa ngokuthuthukisa ukuzwela kwe-insulin.

I-insulin iyi-hormone elawula amazinga kashukela egazini futhi kuye kwabikwa ukuthi inethonya empilweni yamathambo kanye ne-vitamin D metabolism.

I-insulini ikhonjiswe ukuthi yehlisa i-fibroblast growth factor 23 (FGF23), ekhiqizwa amaseli amathambo futhi idlala indima ebalulekile ku-renal phosphate kanye ne-vitamin D metabolism.

I-FGF23 iyihomoni evimbela ngokomzimba i-α-hydroxylase, i-enzyme enesibopho sokuguqula i-vitamin D ibe ifomu layo elisebenzayo. Yehlisa ukwakheka kwe-vitamin D esebenzayo.

Ngakho-ke, amazinga aphezulu e-FGF23 angaholela emazingeni aphansi kavithamini D osebenzayo.

Njengoba kunikezwe ukuthi i-insulin ingakwazi ukulawula i-FGF23, ukwandisa ukuzwela kwe-insulin ngokusebenzisa Ukudla kwe-Ketogenic kungase kuholele emazingeni ancishisiwe e-FGF23 kanye nokwanda okungaba khona kwe-hydroxylated (ifomu elisebenzayo) likavithamini D.

Lokhu kungasikisela ukuthi Izidlo ze-Ketogenic zingase zibe nazo umthelela omuhle ku-vitamin D metabolism.

I-Gut Microbiome

Izidlo ze-Ketogenic ziye zahlongozwa ukuguqula i-gut microbiota ngokunciphisa ukuchichima kwe-Firmicutes nokwandisa ukuchichima kwama-Bacteroidetes nokuhlukahluka kwamagciwane.

Lokhu kungaba nomthelela ekusetshenzisweni kwe-vitamin D, njengoba kunobufakazi bokuthi ama-probiotics angakhuphula amazinga e-vitamin D ajikelezayo futhi athinte amazinga amaprotheni abathuthi bevithamini D, ngaleyo ndlela akhuthaze ukumuncwa kwawo.

Ababhali babike ukuthi abukho ubufakazi obanele bokuthi i-gut microbiome ishintsha kanjani ekudleni kwe-ketogenic ingaba nomthelela emazingeni e-Vitamin D.

Umuntu ngena kulokho! Ngifuna ukwazi! Futhi okwamanje, sizoqhubeka nokufunda zonke izindlela esingazizwa singcono ngazo. Masiqhubeke nokufunda esingakwazi kulokhu kubuyekezwa okuhle kakhulu!

Izitshalo

Kanye nezici zemvelo, ukuhlukahluka kofuzo ezakhini zofuzo ezithintekayo ekuhlanganiseni kwe-cholesterol, i-hydroxylation, kanye nokuthutha kwe-vitamin D kungathinta amazinga kavithamini D.

I-SNP yofuzo (i-nucleotide polymorphism eyodwa) iwuhlobo oluvamile lokuhlukahluka kofuzo olubandakanya ukuguqulwa kwe-nucleotide eyodwa ekulandelaneni kwe-DNA yofuzo. Kungaba nomthelela ekutheni sigcina, sithutha, noma siguqula kahle kangakanani ama-micronutrients abe amafomu atholakala nge-bioavailable.

Ukubuyekezwa kwabo kocwaningo kuhlonze izakhi zofuzo ze-35 kanye nama-SNP amaningana ahlotshaniswa namazinga e-vitamin D, okuphakamisa ukuthi ukuhlukahluka kofuzo kungashintsha izimpendulo zomuntu ngamunye ekudleni kwe-ketogenic.

Kuyingxenye yokuthi kungani oHlelweni lwami Lokubuyisela Inkungu Yengqondo, ngifundisa abantu ukuthi kwenziwa kanjani ukuhlaziywa kwe-nutrigenomics ukuze bakwazi ukwenza ngezifiso ukwesekwa kwabo kwe-Vitamin D nezinye izakhi ezibalulekile ezidingekayo ukuze zibe nempilo enhle yobuchopho.

Uhlelo Lokubuyisela Inkungu Yengqondo

Isiphetho

Ngakho lokho bekuwulwazi OLUNINGI. Ungathanda ukwazi iphuzu eliyinhloko?
Nakhu. Ezifundweni eziningi, ukwanda kokujikeleza kwe-vitamin D kwabikwa.

Zihlole wena kumareferensi uma unentshisekelo!

Okubhekwayo

Detopoulou, P., Papadopoulou, SK, Voulgaridou, G., Dedes, V., Tsoumana, D., Gioxari, A., … & Panoutsopoulos, GI (2022). Ukudla kwe-Ketogenic kanye ne-Vitamin D Metabolism: Ukubuyekezwa Kobufakazi. Ama-Metabolites, 12(12), i-1288. https://doi.org/10.3390/metabo12121288