I-GABA kanye ne-Ketogenic Diets
Isikhathi sokufunda esilinganiselwe: 5 imizuzu
Kudingeka sikhulume ngendima ye-GABA ekuguleni kwengqondo kanye nokuphazamiseka kwezinzwa. Futhi-ke, ngizokuchazela ukuthi kungani ama-ketone angasiza ukulawula le neurotransmitter.
Yini i-GABA?
I-GABA (i-gamma-aminobutyric acid) iyi-neurotransmitter eyinhloko evimbela ebuchosheni, futhi idlala indima ebalulekile ekulawuleni injabulo ye-neuronal kanye nokugcina ibhalansi phakathi kwe-neuronal excitation kanye nokuvinjelwa.
Ukungasebenzi kahle kwe-GABAergic kuye kwathinteka ezinhlobonhlobo zezifo zengqondo nezinzwa, okuhlanganisa ukuphazamiseka kokukhathazeka, ukudangala, isithuthwane, i-schizophrenia, kanye ne-autism spectrum disorders.
Izinguquko ekuboniseni i-GABA zingashintsha ibhalansi phakathi kwe-neurotransmission ejabulisayo nevimbelayo ebuchosheni, okuholela ezimpawu ezihlukahlukene kuye ngokuthi izifunda zobuchopho ezithintekile namasekhethi.
Yiziphi izifo ezibona izinkinga nge-GABA?
Okuningi.
Ukuphazamiseka kokukhathazeka nokudangala kuvame ukubonakala ngokungalingani phakathi kwe-neurotransmission ejabulisayo nevimbelayo ezindaweni zobuchopho ezifana ne-amygdala ne-prefrontal cortex. Ukwehliswa kokusayina kwe-GABA kulezi zifunda kungaholela ekwandeni kwenjabulo ye-neuronal kanye ne-hyperarousal, okungase kube nomthelela ekukhathazekeni nasekuphazamisekeni kwemizwelo.
Isifo sokuwa yisifo sezinzwa esibonakala ngokuquleka okuphindaphindiwe, futhi ngokuvamile sihlotshaniswa nokuphazamiseka ekuboniseni i-GABA. Ukwehliswa kwesignali ye-GABA kungaholela ekusebenzeni kwe-hyperexcitability kanye nomsebenzi wokuthunjwa, kuyilapho ukubonakaliswa kwe-GABA okwandisiwe kungaholela emiphumeleni ye-sedation kanye ne-anticonvulsant.
I-Schizophrenia yisifo sengqondo esiyinkimbinkimbi esihlotshaniswa nokungajwayelekile ezinhlelweni eziningi ze-neurotransmitter, kuhlanganise ne-GABA. Ukwehliswa kokusayina kwe-GABA ku-prefrontal cortex nakwezinye izifunda zobuchopho kuye kwathinteka ekushoda kwengqondo nezimpawu ezinhle (ezifana nokubona izinto ezingekho kanye nokukhohlisa) kwe-schizophrenia.
Izinkinga ze-Autism spectrum ziyizifo ze-neurodevelopmental ezibonakala ngokuphazamiseka kokuxhumana komphakathi kanye nokuziphatha okuphindaphindayo. Ukungasebenzi kahle kwe-GABAergic kuye kwathinteka ku-pathophysiology ye-autism, futhi izinguquko ekuboniseni i-GABA ziye zabonwa ezindaweni eziningana zobuchopho kubantu abane-autism.
I-Ketones ne-GABA
Konke lokhu kuhlangene ngani nokudla kwe-ketogenic? Ngizokutshela. Ngoba ngifuna uqonde zonke izindlela ongazizwa ungcono ngazo. ⬇️
I-D-β-hydroxybutyrate (BHB; umzimba we-ketone) iboniswe ukuthuthukisa ukubonakaliswa kwe-GABA ebuchosheni, okungase kube nemiphumela enenzuzo ekusebenzeni kwengqondo kanye nokuphazamiseka kwezinzwa.
I-Acetoacetate (omunye umzimba we-ketone) ikhonjisiwe futhi ukuguqula ukusayina kwe-GABA ebuchosheni. Sisathola ukuthi kanjani, kodwa umphumela ukhona.
Indlela eyodwa ehlongozwayo yomphumela we-acetoacetate ekuboniseni i-GABA ukuthi ingase ikhulise ukutholakala kwe-GABA ngokuthuthukisa umsebenzi we-GABA-synthesizing enzyme glutamic acid decarboxylase (GAD).
I-GAD (i-enzyme) idinga i-cofactor pyridoxal 5′-phosphate (PLP) ngomsebenzi wayo, futhi i-acetoacetate (umzimba we-ketone) iboniswe ukwandisa ukutholakala kwe-PLP ebuchosheni. Lokhu kungase kubangele ukwanda kwe-GABA synthesis kanye nokukhululwa, okuholela ekuboniseni okuthuthukisiwe kwe-GABA. Kulabo abangazi, i-PLP iwuhlobo olusebenzayo lwe-B6. I-Vitamin B6 ibandakanyeka kumetabolism yama-amino acid, ukuhlanganiswa kwama-neurotransmitters afana ne-serotonin ne-dopamine, kanye nokulawulwa kokubonakaliswa kwezakhi zofuzo.
Qaphela: Yingakho ngithanda ukuhlanganisa ukudla kwe-ketogenic nokukhuphuka kokudla okunomsoco ngesikhathi sokuphulukiswa. Kukhona imiphumela synergistic!
Enye indlela ehlongozwayo ukuthi i-acetoacetate ingase iguqule ama-GABA receptors, okungamaprotheni alamula imiphumela ye-GABA ekujabuleleni kwe-neuronal.
I-Acetoacetate ikhonjiswe ukuthuthukisa umsebenzi wama-GABA-A receptors ebuchosheni. I-GABA iyi-neurotransmitter ebuchosheni esiza ukulawula ukusebenza kobuchopho. Kunezinhlobo ezimbili zama-receptors i-GABA engabopha kuzo, ezibizwa nge-GABA-A kanye ne-GABA-B receptors. Ama-GABA-A receptors asebenza ngokushesha ukuze amise ama-neuron ukuthi angadubuli, kuyilapho ama-GABA-B receptors asebenza kancane ukuze anciphise umsebenzi wobuchopho. Zombili izinhlobo zama-receptors zibalulekile ekugcineni ibhalansi phakathi komsebenzi wobuchopho nokuphumula.
Isiphetho
Ngakho-ke usunakho. Manje usuqonda kabanzi mayelana nokuthi ukudla kwe-ketogenic kusiza kanjani ukulinganisela i-neurotransmitter GABA kanye nemiphumela lokhu okunayo ekwelapheni izifo eziningi zemizwa kanye nezifo zengqondo.
Phuma wenze isinqumo esinolwazi olungcono ekululameni kwakho ekuguleni kwengqondo kanye nokuphazamiseka kwemizwa!
Uma wenza usesho kule bhulogi (phansi kwekhasi) ekuxilongweni kwakho, cishe uzothola isihloko esikhuluma nge-GABA ephazamisekile njengoba sisebenza ekuxilongweni kwakho okuthile. Nazi ezinye zalezo ongase ube nentshisekelo kuzo!
Futhi uma udinga usizo lokufunda ukuthi ungakusebenzisa kanjani ukudla okune-ketogenic nokwenza kube ngokwakho ukwengezwa kwakho kanye nezinguquko zendlela yokuphila uye ebuchosheni obungcono, wamukelekile ukuthi uhlole Uhlelo lwami Lokubuyisela Inkungu Yengqondo.
Okubhekwayo
UBrownlow, ML, Benner, B., D'Agostino, D., Gordon, MN, & Morgan, D. (2020). Ukudla kwe-Ketogenic kuthuthukisa ukukhubazeka kwenkumbulo yendawo okubangelwa ukuchayeka ku-hypoxia ye-hypobaric kumagundane angama-Sprague-Dawley. I-PloS eyodwa, 15(2), e0228763. I-DOI: 10.1371/journal.pone.0228763
Cahill, GF (2006). I-fuel metabolism ekulambeni. Ukubuyekezwa konyaka kokudla okunomsoco, 26, 1-22. I-DOI: 10.1146/annurev.nutr.26.061505.111258
U-D'Andrea Meira, I., Romão, TT, Pires, DO, da Silva-Maia, JK, & de Oliveira, GP (2021). Ukudla kwe-Ketogenic kanye nesifo sokuwa: esikwaziyo kuze kube manje. I-Frontiers ku-neuroscience, 15, 684557. DOI: 10.3389/fnins.2021.684557
U-Lutas, A., & Yellen, G. (2021). Ukudla kwe-ketogenic: imithelela ye-metabolic ekujabuleni kobuchopho kanye nesifo sokuwa. Amathrendi kuma-neuroscience, 44(6), 383-394. I-DOI: 10.1016/j.tins.2021.02.004
U-Newman, JC, & Verdin, E. (2014). Imizimba ye-Ketone njengezimpawu ze-metabolites. Amathrendi ku-endocrinology kanye ne-metabolism, 25(1), 42-52. I-DOI: 10.1016/j.tem.2013.09.002
Sleiman, SF, Henry, J., Al-Haddad, R., El Hayek, L., Abou Haidar, E., Stringer, T., … & Ninan, I. (2016). Ukuzivocavoca kuthuthukisa ukubonakaliswa kwe-brain derived neurotrophic factor (BDNF) ngokusebenzisa isenzo se-ketone body β-hydroxybutyrate. eLife, 5, e15092. I-DOI: 10.7554/eLife.15092
Yamanashi, T., Iwata, YT, & Shibata, M. (2017). Isisekelo se-Neurochemical esingaphansi kokuthuthukiswa kokudluliswa kwe-GABAergic nge-β-hydroxybutyrate ku-hippocampus yegundane. Izincwadi ze-Neuroscience, 643, 35-40. I-DOI: 10.1016/j.neulet.2017.02.019
U-Yudkoff, M., Daikhin, Y., & Nissim, I. (2020). I-Heterogeneity ku-ketone body metabolism ebuchosheni obukhulayo nobuvuthiwe. Ijenali yesifo se-metabolic esizuzwe njengefa, 43(1), 30-37. I-DOI: 10.1002/jimd.12156