Ukuqonda Isayensi Esemuva Kwe-Ketogenic Therapy ye-Major Depressive Disorder
Isikhathi sokufunda esilinganiselwe: 6 imizuzu
Ake sihlole imiphumela yocwaningo oluhlole ubufakazi be-neurobiological obusekela ukuthuthukiswa kokudangala ngokudla okune-ketogenic futhi sithole ukuthi yiziphi izindlela eziyisisekelo zebhayoloji abazithole ngezifundo ze-in vitro kanye ne-vivo ezincwadini zesayensi.
UShamshtein D, uLiwinski T. I-Ketogenic Therapy ye-Major Depressive Disorder: Ukubuyekezwa Kobufakazi Be-Neurobiological. Inqubekelaphambili Yakamuva Kwezokudla2022;2(1):003; doi:10.21926/rpn.2201003.
Ngokuyinhloko, benza ukubuyekezwa kwezincwadi kusukela ngo-Agasti 2021 kuya kuJanuwari 2022. Lokhu kusho ukuthi baseshe izifundo ezibuyekezwe ngontanga befuna idatha mayelana nokusetshenziswa kokudla kwe-ketogenic yokucindezeleka nokuzama ukuthola izindlela ezikhona zokuchaza imiphumela.
Nakhu abakutholile.
I-Glucose Metabolism Engasebenzi
Elinye igama lalokhu yi-brain hypometabolism. Abantu abanokucindezeleka bangase babe nezinguquko ku-glucose metabolism ebuchosheni. Lesi yisimo esibizwa nge-brain hypometabolism. Ukudla kwe-ketogenic kuthuthukisa i-metabolism yamandla eselula ngokukhulisa imizimba ye-ketone nokufaka i-glucose njengomthombo oyinhloko kaphethiloli.
Ama-ketones abuyisela umsebenzi we-mitochondrial futhi asize ukugcina ibhalansi yamandla. Ukudla kwe-ketogenic, okuncike emizimbeni ye-ketone esikhundleni se-glucose, ngokusobala, kungaba yindlela ethembisayo.
I-GABA kanye ne-Glutamate Balance
Uhlelo lwe-glutamate/GABA neurotransmitter lubandakanyeka ekucindezelekeni. Ucwaningo luye lwabonisa amazinga e-glutamate ashintshiwe kubantu abacindezelekile, okuphakamisa injabulo eyeqile ebangelwa i-glutamate ekucindezelekeni.
Umsebenzi owehlisiwe we-GABAergic uhambisana nokucindezeleka, okufana nesifo sokuwa. I-Ketosis, ethuthukisa i-astrocyte metabolism futhi ikhulise ukukhishwa kwe-glutamate, ingase ichaze ukusebenza kahle kwe-ketosis ekwelapheni kokubili isithuthwane nokucindezeleka.
Ukungasebenzi kwe-Mitochondrial kanye ne-Oxidative Stress
I-Mitochondria inesibopho se-metabolism yamandla emangqamuzaneni, futhi ukusebenza kwawo okuncishisiwe kuyathinteka ku-pathogenesis yezifo ze-neurodeergenerative, ezingase zibe nomthelela ekucindezelekeni.
I-Ketosis ingasiza ekudambiseni ukudangala ngokuba nomthelela emitochondrial kanye nezinqubo ze-oxidative, ekugcineni ithuthukise ukusebenza kobuchopho.
Ukungeniswa kwama-molecule aphansi okubonisa i-redox abangelwa imizimba ye-ketone kungase kwandise amazinga e-antioxidant nama-enzyme e-detoxification, futhi kucatshangwa ukuthi lokhu kungase kunciphise ukucindezeleka kwe-oxidative kanye nokungasebenzi kahle kwe-mitochondrial okuhambisana nokucindezeleka.
I-Ketosis kanye Nokuvuvukala
Ababhali bathole izifundo eziningi eziphakamisa ukuhlangana okuqinile phakathi kokudangala nokuvuvukala futhi baphinde bavuma ukuthi kungenzeka ukuthi akusona isimo sokuvuvukala.
Ukuguqulwa kwe-Microglial kucatshangwa ukuthi kudlala indima ebalulekile ye-pathophysiological ekucindezelekeni. I-β-hydroxybutyrate ikhuthaze i-microglial ramification kumagundane anokuziphatha okucindezelayo. Lokhu okutholakele, nokunye okuningi okuvezwe ophenyweni lwabo lwezincwadi zesayensi, kunikeza ubufakazi bemiphumela ye-antidepressant yemizimba ye-ketone ngezenzo zabo ze-immunomodulatory. (13/36) #depression #inflammation #immunomodulation
Ukucindezeleka kungase kube nesixhumanisi esiyimbangela ne-gut microbiota, njengoba kuboniswe ezifundweni ezisekelwe kumodeli yezilwane. Izinguquko ze-Microbiome ezibonwa ezigulini ezicindezelekile ziyefana nalezo ezitholakala kwezinye izifo ezingamahlalakhona njenge-metabolic syndrome.
Ingabe uzizwa udidekile mayelana nomehluko phakathi kwe-neuroinflammation kanye ne-oxidative stress nokuthi zihlobana kanjani? Ungathola lesi sihloko esingezansi siwusizo:
I-Ketosis kanye ne-Gut Microbiome
A ukudla okune-ketogenic kungase kusize ukubuyisela ibhalansi ye-microbial emathunjini, okungenzeka kunciphise umthwalo wezimpawu zokucindezeleka. Amamodeli ezilwane kanye neziguli ezinokuphazamiseka kwengqondo zibonise imiphumela ethembisayo.
Lokhu okutholakele okukhonjwe ezincwadini zesayensi kunikeza isisekelo esiqinile sokufunda imiphumela yokudla kwe-ketogenic ku-gut microbiota kanye nokuthuthukiswa kwezimpawu ezigulini ezinokucindezeleka kanye nezibonelo zezilwane ezinokuziphatha okufana nokucindezeleka.
Ukudla kwe-Ketogenic kanye Nesimo Senhliziyo
Ukucindezeleka kuyinto eyinkimbinkimbi yomuntu okungaba nzima ukuyifunda. Noma kunjalo, izifundo zezilwane zinikeze ukuqonda okubalulekile ezindleleni ezingase zibe khona ze-pathophysiological kanye nezinkomba zokwelapha ezintsha ze-Major Depressive Disorder.
Kumamodeli wamagundane okuziphatha okufana nokucindezeleka, ukudla kwe-ketogenic kwathuthukisa "ukuphelelwa ithemba kokuziphatha", okubonisa ukuthi i-ketosis ingathuthukisa izimpawu zokucindezeleka. Kwezinye izifundo zezilwane, ukondla usawoti we-ketone kanye nosawoti we-ketone oxutshwe ne-medium-chain triglycerides kuthuthukisa ukuziphatha okuhambisana nokukhathazeka e-Sprague-Dawley namagundane e-WAG/Rij, ukufeza i-ketosis phakathi kwezinsuku eziyisikhombisa.
Kuyathakazelisa ukuthi ocwaningweni lwamagundane, ukuchayeka ekudleni kwe-ketogenic kokukhulelwa kwashintsha ukwakheka kobuchopho bengane futhi kwabavikela ekukhathazekeni nasekuziphatheni okuhlobene nokucindezeleka kamuva lapho isikhulile, nakuba inzalo yondliwe i-chow evamile ngemva kokuzalwa.
Ngaphezu kwalokho, ucwaningo lwakamuva lwezilwane lubonise ukuthi ukudla kwe-ketogenic ngokuzivocavoca okuvamile kunciphisa ukukhathazeka nokuziphatha okucindezelayo kumagundane. Ukwehliswa komthwalo wokucindezeleka kwakuhlotshaniswa namazinga e-BHB, okuxhumanisa ukuthuthukiswa kwemizwelo nezinguquko ezinhle ze-metabolic.
Ubufakazi bezokwelapha
Nakuba ubufakazi bokuthuthukiswa kwezimpawu zokucindezeleka kanye nezindlela eziyisisekelo zilinganiselwe, idatha ekhona iyakhuthaza futhi iqinisekisa izifundo ezengeziwe ze-mechanistic emiphumeleni enenzuzo ye-neuromodulator ye-ketosis.
Lapho lesi sihloko socwaningo sishicilelwe, kwakungekho RCTs ephenya ukudla kwe-ketogenic nokucindezeleka! Kodwa ngiyazi okungenani eyodwa eqhubekayo njengoba ngibhala lokhu okuthunyelwe! Ngakho-ke lolu cwaningo lwatholani ngokusekelwe kulokho okwakukhona ngaleso sikhathi ngesikhathi sokudla kwe-ketogenic kwemizwa nokuqonda?
Ucwaningo olulawulwa ngokungahleliwe lwathola ukuthi ukudla okune-ketogenic kunciphisa ukukhathazeka kanye nesimo sengqondo esithuthukisiwe kanye nokuqonda ezinganeni kanye nentsha enesifo sokuwa esiphikisayo uma kuqhathaniswa nokudla okuvamile nokunakekelwa okujwayelekile.
Futhi ezigulini ezindala ezinesithuthwane esingapheli, ukudla kwe-ketogenic kwakuhlotshaniswa nokukhathazeka okuncane nokucindezeleka. Lapho bethatha isikhathi eside ekudleni, kuba nomthelela omuhle kakhulu esimweni sabo sengqondo. Ngicabanga ukuthi kuhle kakhulu lokho.
Ucwaningo lwecala lubonise ukuthi ukudla okune-ketogenic kungase kusebenze njengesiqiniseko semizwelo ezigulini ezinohlobo lwe-II lwe-bipolar disorder. Iziguli zithole ukuzinza kwemizwa okudlula lokho okufezwe ngokusebenzisa imithi.
Ababhali ababuyekeze zonke lezi zifundo ngokucophelela baqhubeka bathi Kubantu, ukudla kwe-ketogenic kuyindlela yokwelapha ephephile futhi ethengekayo enezinzuzo eziningi. Ngokuqondakalayo badinga ucwaningo olwengeziwe ukuze baqonde imiphumela yokudla kwe-ketogenic ekungasebenzini kahle kwe-neurometabolic, ukuvuvukala, kanye nokuguqulwa kwe-commensal microbiota okuhlobene nokudangala. Bangathanda ukubona izifundo ezibonisa ukuhlobana okuqondile phakathi kokudla kwe-ketogenic kanye nokunciphisa izimpawu zokudangala.
Kodwa masikhulume iqiniso. Kuzothatha isikhathi ukuthi lezo zifundo zenziwe. Futhi abantu bayahlupheka manje.
Baphetha ukubuyekezwa kwabo kwezincwadi ngesiphetho esilandelayo.
Noma kunjalo, ubufakazi obutholakalayo busekela ngokuqinile ukuqaliswa kokuhlolwa okulawulwa ngokungahleliwe okubandakanya ukusetshenziswa kokudla kwe-ketogenic kubantu abacindezelekile.
Futhi ngenkathi lezi zivivinyo ezilawulwa ngokungahleliwe kubantu abacindezelekile zihlelwa futhi ziqhubeka, angazi ngawe, kodwa ngizoqinisekisa ukuthi amaklayenti ami ayazi ngemibhalo. Bafanele ukwazi ukuthi ukudla kwe-ketogenic kubonisa izinzuzo ezingaba khona kuma-comorbidities ajwayelekile kanye nama-pathologies abonwa ku-Major Depressive Disorder.
Alukho uxhaso oluningi olutholakalayo lokungenelela kokudla ngaphandle uma ubala Iqembu le-Baszucki kanye nabalingani babo abazoshintsha izimpilo ezingenakubalwa ngokuxhasa ngezimali izifundo ezidingekayo ukuze kusetshenziswe lokhu kwelashwa okunamandla kwe-metabolic kwezifo zengqondo kanye nokuphazamiseka kwemizwa.
Naphezu kwalolu hlu lwezifiso zocwaningo olwengeziwe, abacwaningi bocwaningo baqhubeka besho ukuthi idatha ekhona iphakamisa izinzuzo ezingaba khona zokudla kwe-ketogenic ngokumelene ne-Major Depressive Disorder (MDD) kuma-comorbidities ajwayelekile noma izici ze-pathological intersecting.
Ngiyakwazi ukutshela iziguli zami ukuthi akulona izinga lokunakekelwa ngemva kokuzinikeza izinga lokunakekelwa. Futhi usalokhu usesimweni sokuziphatha. Ngoba ukungabelani ngalokhu kwelashwa okubonisa izithembiso ezingaka kulabo abaphethwe I-Major Depressive Disorder, engqondweni yami, kungaba yingozi futhi kungabi isimo sokuziphatha.
Nasi isifundo ukuze kube lula kuwe uma ufuna imininingwane eyengeziwe. Ngakho ungaba nolwazi oludingayo ukuze uzikhethele izimiso zokuziphatha njengodokotela, Noma mhlawumbe ubukele othile omthandayo ehlupheka. Futhi ungathanda ukuthi bazi zonke izindlela abangazizwa bengcono ngazo.
Uma ungathanda ukufunda okwengeziwe mayelana nezinqubo ezingaba khona zesenzo ekudleni kwe-ketogenic ekucindezelekeni, ungase ujabulele lezi ezinye izihloko zebhulogi ezitholakala lapha ku-Mental Health Keto Blog.
Ngoba unelungelo lokwazi zonke izindlela ongazizwa ungcono ngazo.